Cover Image

Association of viral load with TRAIL, IP-10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source: a prospective, multicentre cohort study

Background To investigate the association of viral load (VL) with (i) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10, C-reactive protein, and a combinatorial score (BV score), and (ii) clinical severity. Study Design In this prospective, multicen...

Full description

Saved in:
Bibliographic Details
Main Authors: Papan, Cihan (Author) , Argentiero, Alberto (Author) , Adams, Ortwin (Author) , Porwoll, Marian (Author) , Hakim, Ummaya (Author) , Farinelli, Edoardo (Author) , Testa, Ilaria (Author) , Pasticci, Maria B. (Author) , Mezzetti, Daniele (Author) , Perruccio, Katia (Author) , Simon, Arne (Author) , Liese, Johannes G. (Author) , Knuf, Markus (Author) , Stein, Michal (Author) , Yacobov, Renata (Author) , Bamberger, Ellen (Author) , Schneider, Sven (Author) , Esposito, Susanna (Author) , Tenenbaum, Tobias (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Journal of medical virology
Year: 2023, Volume: 95, Issue: 1, Pages: 1-11
ISSN:1096-9071
DOI:10.1002/jmv.28113
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/jmv.28113
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.28113
Get full text
Author Notes:Cihan Papan, Alberto Argentiero, Ortwin Adams, Marian Porwoll, Ummaya Hakim, Edoardo Farinelli, Ilaria Testa, Maria B. Pasticci, Daniele Mezzetti, Katia Perruccio, Arne Simon, Johannes G. Liese, Markus Knuf, Michal Stein, Renata Yacobov, Ellen Bamberger, Sven Schneider, Susanna Esposito, Tobias Tenenbaum

MARC

LEADER 00000caa a2200000 c 4500
001 1846233593
003 DE-627
005 20230706205212.0
007 cr uuu---uuuuu
008 230525s2023 xx |||||o 00| ||eng c
024 7 |a 10.1002/jmv.28113  |2 doi 
035 |a (DE-627)1846233593 
035 |a (DE-599)KXP1846233593 
035 |a (OCoLC)1389529796 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Papan, Cihan  |d 1984-  |e VerfasserIn  |0 (DE-588)1076370381  |0 (DE-627)834800187  |0 (DE-576)44524805X  |4 aut 
245 1 0 |a Association of viral load with TRAIL, IP-10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source: a prospective, multicentre cohort study  |c Cihan Papan, Alberto Argentiero, Ortwin Adams, Marian Porwoll, Ummaya Hakim, Edoardo Farinelli, Ilaria Testa, Maria B. Pasticci, Daniele Mezzetti, Katia Perruccio, Arne Simon, Johannes G. Liese, Markus Knuf, Michal Stein, Renata Yacobov, Ellen Bamberger, Sven Schneider, Susanna Esposito, Tobias Tenenbaum 
264 1 |c 2023 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a First published: 31 August 2022 
500 |a Gesehen am 25.05.2023 
520 |a Background To investigate the association of viral load (VL) with (i) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10, C-reactive protein, and a combinatorial score (BV score), and (ii) clinical severity. Study Design In this prospective, multicentre cohort substudy, children with respiratory tract infection or fever without source were enrolled. VL for influenza virus, rhinovirus, respiratory syncytial virus, and adenovirus was measured from nasopharyngeal swabs. The reference standard diagnosis was established based on expert panel adjudication. Results Of 1140 recruited patients, 333 had a virus monodetection. VL for the aggregated data set correlated with TRAIL and IP-10 levels, with the length of oxygen therapy, and inversely with the BV score. At a single viral level, only the influenza VL yielded a correlation with TRAIL, IP-10 levels, and the BV score. Children with a viral reference standard diagnosis had significantly higher VL than those with bacterial infection (p = 0.0005). Low TRAIL (incidence rate ratio [IRR] 0.6, 95% confidence interval [CI] 0.39-0.91) and young age (IRR 0.62, 95% CI 0.49-0.79) were associated with a longer hospital stay, while young age (IRR 0.33, 95% CI 0.18-0.61), low TRAIL (IRR 0.25, 95% CI 0.08-0.76), and high VL (IRR 1.16, 95% CI 1.00-1.33) were predictive of longer oxygen therapy. Conclusion These findings indicate that VL correlates with biomarkers and may serve as a complementary tool pertaining to disease severity. 
650 4 |a adenovirus 
650 4 |a biomarkers 
650 4 |a CRP 
650 4 |a host response 
650 4 |a host-protein signature 
650 4 |a influenza 
650 4 |a IP-10 
650 4 |a rhinovirus 
650 4 |a RSV 
650 4 |a severity 
650 4 |a TRAIL 
650 4 |a viral load 
700 1 |a Argentiero, Alberto  |e VerfasserIn  |4 aut 
700 1 |a Adams, Ortwin  |e VerfasserIn  |4 aut 
700 1 |a Porwoll, Marian  |d 1988-  |e VerfasserIn  |0 (DE-588)1290823030  |0 (DE-627)1846946077  |4 aut 
700 1 |a Hakim, Ummaya  |e VerfasserIn  |4 aut 
700 1 |a Farinelli, Edoardo  |e VerfasserIn  |4 aut 
700 1 |a Testa, Ilaria  |e VerfasserIn  |4 aut 
700 1 |a Pasticci, Maria B.  |e VerfasserIn  |4 aut 
700 1 |a Mezzetti, Daniele  |e VerfasserIn  |4 aut 
700 1 |a Perruccio, Katia  |e VerfasserIn  |4 aut 
700 1 |a Simon, Arne  |e VerfasserIn  |4 aut 
700 1 |a Liese, Johannes G.  |e VerfasserIn  |4 aut 
700 1 |a Knuf, Markus  |d 1963-  |e VerfasserIn  |0 (DE-588)113536887  |0 (DE-627)664962173  |0 (DE-576)347721222  |4 aut 
700 1 |a Stein, Michal  |e VerfasserIn  |4 aut 
700 1 |a Yacobov, Renata  |e VerfasserIn  |4 aut 
700 1 |a Bamberger, Ellen  |e VerfasserIn  |4 aut 
700 1 |a Schneider, Sven  |e VerfasserIn  |4 aut 
700 1 |a Esposito, Susanna  |e VerfasserIn  |0 (DE-588)120865327X  |0 (DE-627)1694970574  |4 aut 
700 1 |a Tenenbaum, Tobias  |d 1973-  |e VerfasserIn  |0 (DE-588)128399155  |0 (DE-627)372640109  |0 (DE-576)302559752  |4 aut 
773 0 8 |i Enthalten in  |t Journal of medical virology  |d Bognor Regis [u.a.] : Wiley, 1977  |g 95(2023), 1, Artikel-ID e28113, Seite 1-11  |h Online-Ressource  |w (DE-627)269535268  |w (DE-600)1475090-9  |w (DE-576)079718744  |x 1096-9071  |7 nnas  |a Association of viral load with TRAIL, IP-10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source: a prospective, multicentre cohort study 
773 1 8 |g volume:95  |g year:2023  |g number:1  |g elocationid:e28113  |g pages:1-11  |g extent:11  |a Association of viral load with TRAIL, IP-10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source: a prospective, multicentre cohort study 
856 4 0 |u https://doi.org/10.1002/jmv.28113  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.28113  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20230525 
993 |a Article 
994 |a 2023 
998 |g 1290823030  |a Porwoll, Marian  |m 1290823030:Porwoll, Marian  |d 60000  |e 60000PP1290823030  |k 0/60000/  |p 4 
999 |a KXP-PPN1846233593  |e 4325227156 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"disp":"Association of viral load with TRAIL, IP-10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source: a prospective, multicentre cohort studyJournal of medical virology","note":["Gesehen am 28.02.08"],"recId":"269535268","type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title_sort":"Journal of medical virology","title":"Journal of medical virology"}],"pubHistory":["1.1977 -"],"part":{"issue":"1","volume":"95","extent":"11","pages":"1-11","year":"2023","text":"95(2023), 1, Artikel-ID e28113, Seite 1-11"},"origin":[{"dateIssuedDisp":"1977-","publisher":"Wiley","publisherPlace":"Bognor Regis [u.a.]","dateIssuedKey":"1977"}],"id":{"eki":["269535268"],"doi":["10.1002/(ISSN)1096-9071"],"issn":["1096-9071"],"zdb":["1475090-9"]},"language":["eng"]}],"physDesc":[{"extent":"11 S."}],"name":{"displayForm":["Cihan Papan, Alberto Argentiero, Ortwin Adams, Marian Porwoll, Ummaya Hakim, Edoardo Farinelli, Ilaria Testa, Maria B. Pasticci, Daniele Mezzetti, Katia Perruccio, Arne Simon, Johannes G. Liese, Markus Knuf, Michal Stein, Renata Yacobov, Ellen Bamberger, Sven Schneider, Susanna Esposito, Tobias Tenenbaum"]},"note":["First published: 31 August 2022","Gesehen am 25.05.2023"],"recId":"1846233593","type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"roleDisplay":"VerfasserIn","family":"Papan","given":"Cihan","display":"Papan, Cihan","role":"aut"},{"family":"Argentiero","roleDisplay":"VerfasserIn","given":"Alberto","display":"Argentiero, Alberto","role":"aut"},{"family":"Adams","roleDisplay":"VerfasserIn","role":"aut","display":"Adams, Ortwin","given":"Ortwin"},{"role":"aut","display":"Porwoll, Marian","given":"Marian","roleDisplay":"VerfasserIn","family":"Porwoll"},{"display":"Hakim, Ummaya","role":"aut","given":"Ummaya","roleDisplay":"VerfasserIn","family":"Hakim"},{"roleDisplay":"VerfasserIn","family":"Farinelli","display":"Farinelli, Edoardo","role":"aut","given":"Edoardo"},{"display":"Testa, Ilaria","role":"aut","given":"Ilaria","roleDisplay":"VerfasserIn","family":"Testa"},{"roleDisplay":"VerfasserIn","family":"Pasticci","given":"Maria B.","display":"Pasticci, Maria B.","role":"aut"},{"family":"Mezzetti","roleDisplay":"VerfasserIn","display":"Mezzetti, Daniele","role":"aut","given":"Daniele"},{"family":"Perruccio","roleDisplay":"VerfasserIn","role":"aut","display":"Perruccio, Katia","given":"Katia"},{"roleDisplay":"VerfasserIn","family":"Simon","role":"aut","display":"Simon, Arne","given":"Arne"},{"roleDisplay":"VerfasserIn","family":"Liese","display":"Liese, Johannes G.","role":"aut","given":"Johannes G."},{"given":"Markus","role":"aut","display":"Knuf, Markus","roleDisplay":"VerfasserIn","family":"Knuf"},{"display":"Stein, Michal","role":"aut","given":"Michal","family":"Stein","roleDisplay":"VerfasserIn"},{"given":"Renata","display":"Yacobov, Renata","role":"aut","family":"Yacobov","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Bamberger, Ellen","given":"Ellen","family":"Bamberger","roleDisplay":"VerfasserIn"},{"family":"Schneider","roleDisplay":"VerfasserIn","given":"Sven","display":"Schneider, Sven","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Esposito","given":"Susanna","role":"aut","display":"Esposito, Susanna"},{"roleDisplay":"VerfasserIn","family":"Tenenbaum","display":"Tenenbaum, Tobias","role":"aut","given":"Tobias"}],"title":[{"title":"Association of viral load with TRAIL, IP-10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source: a prospective, multicentre cohort study","title_sort":"Association of viral load with TRAIL, IP-10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source: a prospective, multicentre cohort study"}],"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"2023"}],"id":{"doi":["10.1002/jmv.28113"],"eki":["1846233593"]},"language":["eng"]} 
SRT |a PAPANCIHANASSOCIATIO2023 

Similar Items