Impact of disease-modifying therapies on evolving tissue damage in iron rim multiple sclerosis lesions: short report
We investigated the impact of disease-modifying therapies (DMTs) on the evolving tissue damage in iron rim multiple sclerosis lesions using a novel post-processing magnetic resonance imaging (MRI) approach, the T1/T2 ratio. In this study, on baseline and 1-year follow-up, T1/T2 ratios of iron rim le...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 2022
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| In: |
Multiple sclerosis journal
Year: 2022, Jahrgang: 28, Heft: 14, Pages: 2294-2298 |
| ISSN: | 1477-0970 |
| DOI: | 10.1177/13524585221106338 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/13524585221106338
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| Verfasserangaben: | Philipp Eisele, Matthias Wittayer, Claudia E Weber, Michael Platten, Lucas Schirmer and Achim Gass |
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| 520 | |a We investigated the impact of disease-modifying therapies (DMTs) on the evolving tissue damage in iron rim multiple sclerosis lesions using a novel post-processing magnetic resonance imaging (MRI) approach, the T1/T2 ratio. In this study, on baseline and 1-year follow-up, T1/T2 ratios of iron rim lesions (IRLs) in patients starting DMT (dimethyl fumarate, fingolimod, ocrelizumab) did not statistically differ compared to patients without DMT. At the second follow-up, T1/T2 ratios were significantly lower in IRLs in patients without DMT (p = 0.002), suggesting that DMTs have a beneficial delayed effect on lesion evolution and tissue matrix damage in IRLs. | ||
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