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Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis

The prognosis for lung cancer patients treated with chemotherapy is poor. Single nucleotide polymorphisms (SNPs) in matrix metalloproteinase (MMP) genes could influence treatment outcome by altering apoptotic pathways. Eight SNPs with known or suspected phenotypic effect in six genes (MMP1, MMP2, MM...

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Bibliographic Details
Main Authors: Scherf, David (Author) , Dally, Heike (Author) , Müller, Phillip (Author) , Werle-Schneider, Gisela (Author) , Jäger, B. (Author) , Edler, Lutz (Author) , Tuengerthal, Siegfried (Author) , Fischer, Jürgen (Author) , Drings, Peter (Author) , Bartsch, Helmut (Author) , Risch, Angela (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: The European respiratory journal
Year: 2010, Volume: 35, Issue: 2, Pages: 381-390
ISSN:1399-3003
DOI:10.1183/09031936.00125608
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1183/09031936.00125608
Verlag, lizenzpflichtig, Volltext: https://erj.ersjournals.com/content/35/2/381
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Author Notes:D.B. Scherf, H. Dally, P. Müller, G. Werle-Schneider, B. Jäger, L. Edler, S. Tuengerthal, J.R. Fischer, P. Drings, H. Bartsch and A. Risch
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Summary:The prognosis for lung cancer patients treated with chemotherapy is poor. Single nucleotide polymorphisms (SNPs) in matrix metalloproteinase (MMP) genes could influence treatment outcome by altering apoptotic pathways. Eight SNPs with known or suspected phenotypic effect in six genes (MMP1, MMP2, MMP3, MMP7, MMP9 and MMP12) were investigated.
Item Description:Online veröffentlicht am 30. Juli 2009
Gesehen am 06.06.2023
Physical Description:Online Resource
ISSN:1399-3003
DOI:10.1183/09031936.00125608

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