Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in experimental models of Huntington’s disease

Huntington’s disease (HD) is a fatal neurodegenerative disorder with no effective cure currently available. Over the past few years our research has shown that alterations in sphingolipid metabolism represent a critical determinant in HD pathogenesis. In particular, aberrant metabolism of sphingosin...

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Main Authors:	Pepe, Giuseppe (Author) , Capocci, Luca (Author) , Marracino, Federico (Author) , Realini, Natalia (Author) , Lenzi, Paola (Author) , Martinello, Katiuscia (Author) , Bovier, Tiziana Francesca (Author) , Bichell, Terry Jo (Author) , Scarselli, Pamela (Author) , Di Cicco, Clotilde (Author) , Bowman, Aaron B. (Author) , Digilio, Filomena A. (Author) , Fucile, Sergio (Author) , Fornai, Francesco (Author) , Armirotti, Andrea (Author) , Parlato, Rosanna (Author) , Di Pardo, Alba (Author) , Maglione, Vittorio (Author)
Format:	Article (Journal)
Language:	English
Published:	4 January 2023
In:	Molecular therapy Year: 2023, Volume: 31, Issue: 1, Pages: 282-299
ISSN:	1525-0024
DOI:	10.1016/j.ymthe.2022.09.004
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ymthe.2022.09.004 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1525001622005585
Author Notes:	Giuseppe Pepe, Luca Capocci, Federico Marracino, Natalia Realini, Paola Lenzi, Katiuscia Martinello, Tiziana Francesca Bovier, Terry Jo Bichell, Pamela Scarselli, Clotilde Di Cicco, Aaron B. Bowman, Filomena A. Digilio, Sergio Fucile, Francesco Fornai, Andrea Armirotti, Rosanna Parlato, Alba Di Pardo, Vittorio Maglione