Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomas
PURPOSE: To evaluate the outcomes of patients with vestibular schwannoma (VS) treated with fractionated stereotactic radiotherapy (FSRT) vs. those treated with stereotactic radiosurgery (SRS). - METHODS AND MATERIALS: This study is based on an analysis of 200 patients with 202 VSs treated with FSRT...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010
|
| In: |
International journal of radiation oncology, biology, physics
Year: 2010, Jahrgang: 76, Heft: 1, Pages: 193-200 |
| ISSN: | 1879-355X |
| DOI: | 10.1016/j.ijrobp.2009.01.064 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2009.01.064
|
| Verfasserangaben: | Stephanie E. Combs, M.D., Thomas Welzel, M.D., Daniela Schulz-Ertner, M.D., Peter E. Huber, M.D., PH.D., and Jürgen Debus, M.D., PH.D. |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1847496024 | ||
| 003 | DE-627 | ||
| 005 | 20230710131442.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230606s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijrobp.2009.01.064 |2 doi | |
| 035 | |a (DE-627)1847496024 | ||
| 035 | |a (DE-599)KXP1847496024 | ||
| 035 | |a (OCoLC)1389794253 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Combs, Stephanie |d 1976- |e VerfasserIn |0 (DE-588)124782515 |0 (DE-627)366051245 |0 (DE-576)294499741 |4 aut | |
| 245 | 1 | 0 | |a Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomas |c Stephanie E. Combs, M.D., Thomas Welzel, M.D., Daniela Schulz-Ertner, M.D., Peter E. Huber, M.D., PH.D., and Jürgen Debus, M.D., PH.D. |
| 264 | 1 | |c 2010 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 13 July 2009 | ||
| 500 | |a Gesehen am 06.06.2023 | ||
| 520 | |a PURPOSE: To evaluate the outcomes of patients with vestibular schwannoma (VS) treated with fractionated stereotactic radiotherapy (FSRT) vs. those treated with stereotactic radiosurgery (SRS). - METHODS AND MATERIALS: This study is based on an analysis of 200 patients with 202 VSs treated with FSRT (n = 172) or SRS (n = 30). Patients with tumor progression and/or progression of clinical symptoms were selected for treatment. In 165 out of 202 VSs (82%), RT was performed as the primary treatment for VS, and for 37 VSs (18%), RT was conducted for tumor progression after neurosurgical intervention. For patients receiving FSRT, a median total dose of 57.6 Gy was prescribed, with a median fractionation of 5 x 1.8 Gy per week. For patients who underwent SRS, a median single dose of 13 Gy was prescribed to the 80% isodose. - RESULTS: FSRT and SRS were well tolerated. Median follow-up time was 75 months. Local control was not statistically different for both groups. The probability of maintaining the pretreatment hearing level after SRS with doses of < or =13 Gy was comparable to that of FSRT. The radiation dose for the SRS group (< or =13 Gy vs. >13 Gy) significantly influenced hearing preservation rates (p = 0.03). In the group of patients treated with SRS doses of < or =13 Gy, cranial nerve toxicity was comparable to that of the FSRT group. - CONCLUSIONS: FSRT and SRS are both safe and effective alternatives for the treatment of VS. Local control rates are comparable in both groups. SRS with doses of < or =13 Gy is a safe alternative to FSRT. While FSRT can be applied safely for the treatment of VSs of all sizes, SRS should be reserved for smaller lesions. | ||
| 650 | 4 | |a Dose Fractionation, Radiation | |
| 650 | 4 | |a Facial Nerve | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Follow-Up Studies | |
| 650 | 4 | |a Hearing | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Neuroma, Acoustic | |
| 650 | 4 | |a Radiosurgery | |
| 650 | 4 | |a Trigeminal Nerve | |
| 700 | 1 | |a Welzel, Thomas |d 1967- |e VerfasserIn |0 (DE-588)1056889012 |0 (DE-627)794179746 |0 (DE-576)412868164 |4 aut | |
| 700 | 1 | |a Schulz-Ertner, Daniela |e VerfasserIn |0 (DE-588)1076348246 |0 (DE-627)834742438 |0 (DE-576)187377030 |4 aut | |
| 700 | 1 | |a Huber, Peter E. |d 1965- |e VerfasserIn |0 (DE-588)1074678869 |0 (DE-627)832350109 |0 (DE-576)442767803 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of radiation oncology, biology, physics |d Amsterdam [u.a.] : Elsevier Science, 1975 |g 76(2010), 1, Seite 193-200 |h Online-Ressource |w (DE-627)306659662 |w (DE-600)1500486-7 |w (DE-576)081986319 |x 1879-355X |7 nnas |a Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomas |
| 773 | 1 | 8 | |g volume:76 |g year:2010 |g number:1 |g pages:193-200 |g extent:8 |a Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomas |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijrobp.2009.01.064 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230606 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |d 50000 |d 130000 |e 910000PD1022671421 |e 911400PD1022671421 |e 50000PD1022671421 |e 130000PD1022671421 |k 0/910000/ |k 1/910000/911400/ |k 0/50000/ |k 0/130000/ |p 5 |y j | ||
| 998 | |g 1074678869 |a Huber, Peter E. |m 1074678869:Huber, Peter E. |d 50000 |e 50000PH1074678869 |k 0/50000/ |p 4 | ||
| 998 | |g 1076348246 |a Schulz-Ertner, Daniela |m 1076348246:Schulz-Ertner, Daniela |d 50000 |e 50000PS1076348246 |k 0/50000/ |p 3 | ||
| 998 | |g 1056889012 |a Welzel, Thomas |m 1056889012:Welzel, Thomas |d 910000 |d 911400 |e 910000PW1056889012 |e 911400PW1056889012 |k 0/910000/ |k 1/910000/911400/ |p 2 | ||
| 998 | |g 124782515 |a Combs, Stephanie |m 124782515:Combs, Stephanie |d 910000 |d 911400 |e 910000PC124782515 |e 911400PC124782515 |k 0/910000/ |k 1/910000/911400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1847496024 |e 4329654784 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"8 S."}],"recId":"1847496024","note":["Available online 13 July 2009","Gesehen am 06.06.2023"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomas","title":"Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomas"}],"person":[{"display":"Combs, Stephanie","family":"Combs","given":"Stephanie","role":"aut"},{"role":"aut","given":"Thomas","family":"Welzel","display":"Welzel, Thomas"},{"display":"Schulz-Ertner, Daniela","role":"aut","given":"Daniela","family":"Schulz-Ertner"},{"display":"Huber, Peter E.","family":"Huber","role":"aut","given":"Peter E."},{"display":"Debus, Jürgen","role":"aut","given":"Jürgen","family":"Debus"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"recId":"306659662","disp":"Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomasInternational journal of radiation oncology, biology, physics","origin":[{"dateIssuedKey":"1975","dateIssuedDisp":"1975-","publisherPlace":"Amsterdam [u.a.]","publisher":"Elsevier Science"}],"pubHistory":["1.1975/76 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 15.01.20","Ungezählte Beil.: Supplement"],"id":{"zdb":["1500486-7"],"issn":["1879-355X"],"eki":["306659662"]},"title":[{"subtitle":"the official journal of the American Society for Therapeutic Radiology and Oncology","title_sort":"International journal of radiation oncology, biology, physics","title":"International journal of radiation oncology, biology, physics"}],"part":{"issue":"1","text":"76(2010), 1, Seite 193-200","extent":"8","pages":"193-200","volume":"76","year":"2010"}}],"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"2010"}],"id":{"eki":["1847496024"],"doi":["10.1016/j.ijrobp.2009.01.064"]},"name":{"displayForm":["Stephanie E. Combs, M.D., Thomas Welzel, M.D., Daniela Schulz-Ertner, M.D., Peter E. Huber, M.D., PH.D., and Jürgen Debus, M.D., PH.D."]}} | ||
| SRT | |a COMBSSTEPHDIFFERENCE2010 | ||