Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomas
PURPOSE: To evaluate the outcomes of patients with vestibular schwannoma (VS) treated with fractionated stereotactic radiotherapy (FSRT) vs. those treated with stereotactic radiosurgery (SRS). - METHODS AND MATERIALS: This study is based on an analysis of 200 patients with 202 VSs treated with FSRT...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2010
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| In: |
International journal of radiation oncology, biology, physics
Year: 2010, Volume: 76, Issue: 1, Pages: 193-200 |
| ISSN: | 1879-355X |
| DOI: | 10.1016/j.ijrobp.2009.01.064 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2009.01.064
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| Author Notes: | Stephanie E. Combs, M.D., Thomas Welzel, M.D., Daniela Schulz-Ertner, M.D., Peter E. Huber, M.D., PH.D., and Jürgen Debus, M.D., PH.D. |
MARC
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| 245 | 1 | 0 | |a Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomas |c Stephanie E. Combs, M.D., Thomas Welzel, M.D., Daniela Schulz-Ertner, M.D., Peter E. Huber, M.D., PH.D., and Jürgen Debus, M.D., PH.D. |
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| 520 | |a PURPOSE: To evaluate the outcomes of patients with vestibular schwannoma (VS) treated with fractionated stereotactic radiotherapy (FSRT) vs. those treated with stereotactic radiosurgery (SRS). - METHODS AND MATERIALS: This study is based on an analysis of 200 patients with 202 VSs treated with FSRT (n = 172) or SRS (n = 30). Patients with tumor progression and/or progression of clinical symptoms were selected for treatment. In 165 out of 202 VSs (82%), RT was performed as the primary treatment for VS, and for 37 VSs (18%), RT was conducted for tumor progression after neurosurgical intervention. For patients receiving FSRT, a median total dose of 57.6 Gy was prescribed, with a median fractionation of 5 x 1.8 Gy per week. For patients who underwent SRS, a median single dose of 13 Gy was prescribed to the 80% isodose. - RESULTS: FSRT and SRS were well tolerated. Median follow-up time was 75 months. Local control was not statistically different for both groups. The probability of maintaining the pretreatment hearing level after SRS with doses of < or =13 Gy was comparable to that of FSRT. The radiation dose for the SRS group (< or =13 Gy vs. >13 Gy) significantly influenced hearing preservation rates (p = 0.03). In the group of patients treated with SRS doses of < or =13 Gy, cranial nerve toxicity was comparable to that of the FSRT group. - CONCLUSIONS: FSRT and SRS are both safe and effective alternatives for the treatment of VS. Local control rates are comparable in both groups. SRS with doses of < or =13 Gy is a safe alternative to FSRT. While FSRT can be applied safely for the treatment of VSs of all sizes, SRS should be reserved for smaller lesions. | ||
| 650 | 4 | |a Dose Fractionation, Radiation | |
| 650 | 4 | |a Facial Nerve | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Follow-Up Studies | |
| 650 | 4 | |a Hearing | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Neuroma, Acoustic | |
| 650 | 4 | |a Radiosurgery | |
| 650 | 4 | |a Trigeminal Nerve | |
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