Lipocalin 2 - mutation screen and serum levels in patients with anorexia nervosa or obesity and in lean individuals
Context: The bone-derived adipokine lipocalin-2 is relevant for body weight regulation by stimulating the leptin-melanocortin pathway. Objective: We aimed to (i) detect variants in the lipocalin-2 gene (LCN2) which are relevant for body weight regulation and/or anorexia nervosa (AN); (ii) describe a...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 March 2023
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| In: |
Frontiers in endocrinology
Year: 2023, Jahrgang: 14, Pages: 1-12 |
| ISSN: | 1664-2392 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fendo.2023.1137308
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| Verfasserangaben: | Yiran Zheng, Luisa Sophie Rajcsanyi, Manuela Kowalczyk, Johanna Giuranna, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, Stephan Zipfel, Katrin Giel, Karin Egberts, Roland Burghardt, Manuel Föcker, Saad Al-Lahham, Johannes Hebebrand, Dagmar Fuhrer, Susanne Tan, Denise Zwanziger, Triinu Peters and Anke Hinney |
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| 245 | 1 | 0 | |a Lipocalin 2 - mutation screen and serum levels in patients with anorexia nervosa or obesity and in lean individuals |c Yiran Zheng, Luisa Sophie Rajcsanyi, Manuela Kowalczyk, Johanna Giuranna, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, Stephan Zipfel, Katrin Giel, Karin Egberts, Roland Burghardt, Manuel Föcker, Saad Al-Lahham, Johannes Hebebrand, Dagmar Fuhrer, Susanne Tan, Denise Zwanziger, Triinu Peters and Anke Hinney |
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| 520 | |a Context: The bone-derived adipokine lipocalin-2 is relevant for body weight regulation by stimulating the leptin-melanocortin pathway. Objective: We aimed to (i) detect variants in the lipocalin-2 gene (LCN2) which are relevant for body weight regulation and/or anorexia nervosa (AN); (ii) describe and characterize the impact of LCN2 and MC4R variants on circulating lipocalin-2 level. Methods: Sanger sequencing of the coding region of LCN2 in 284 children and adolescents with severe obesity or 287 patients with anorexia nervosa. In-silico analyses to evaluate functional implications of detected LCN2 variants. TaqMan assays for rare non-synonymous variants (NSVs) in additional independent study groups. Serum levels of lipocalin-2 were measured by ELISA in 35 females with NSVs in either LCN2 or MC4R, and 33 matched controls without NSVs in the two genes. Results: Fourteen LCN2-variants (five NSVs) were detected. LCN2-p.Leu6Pro and p.Gly9Val located in the highly conserved signal peptide region may induce functional consequences. The secondary structure change of lipocalin-2 due to LCN2-p.Val89Ile may decrease solubility and results in a low lipocalin-2 level in a heterozygotes carrier (female recovered from AN). Lean individuals had lower lipocalin-2 levels compared to patients with obesity (p = 0.033). Conclusion: Lipocalin-2 levels are positively associated with body mass index (BMI). Single LCN2-variants might have a profound effect on lipocalin-2 levels. | ||
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| 700 | 1 | |a Kowalczyk, Manuela |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Herpertz-Dahlmann, Beate |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seitz, Jochen |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Giel, Katrin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Egberts, Karin M. |e VerfasserIn |0 (DE-588)1303833786 |0 (DE-627)1860204929 |4 aut | |
| 700 | 1 | |a Burghardt, Roland |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Fuhrer, Dagmar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tan, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zwanziger, Denise |e VerfasserIn |4 aut | |
| 700 | 1 | |a Peters, Triinu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hinney, Anke |e VerfasserIn |4 aut | |
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