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Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents

The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro electrophysiology data, however, show a markedly different dors...

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Bibliographische Detailangaben
Hauptverfasser: Ohara, Shinya (VerfasserIn) , Rannap, Märt (VerfasserIn) , Tsutsui, Ken-Ichiro (VerfasserIn) , Draguhn, Andreas (VerfasserIn) , Egorov, Alexei (VerfasserIn) , Witter, Menno P. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 31 January 2023
In: Cell reports
Year: 2023, Jahrgang: 42, Heft: 1, Pages: 1-19
ISSN:2211-1247
DOI:10.1016/j.celrep.2023.112001
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.celrep.2023.112001
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2211124723000128
Volltext
Verfasserangaben:Shinya Ohara, Märt Rannap, Ken-Ichiro Tsutsui, Andreas Draguhn, Alexei V. Egorov, and Menno P. Witter
Beschreibung
Zusammenfassung:The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro electrophysiology data, however, show a markedly different dorsoventral organization of the hippocampal projection to the medial EC (MEC). While dorsal hippocampal projections are confined to the dorsal MEC, ventral hippocampal projections innervate both dorsal and ventral MEC. Further, whereas the dorsal hippocampus preferentially targets layer Vb (LVb) neurons, the ventral hippocampus mainly targets cells in layer Va (LVa). This connectivity scheme differs from hippocampal projections to the lateral EC, which are topographically organized along the dorsoventral axis. As LVa neurons project to telencephalic structures, our findings indicate that the ventral hippocampus regulates LVa-mediated entorhinal-neocortical output from both dorsal and ventral MEC. Overall, the marked dorsoventral differences in hippocampal-entorhinal connectivity impose important constraints on signal flow in hippocampal-neocortical circuits.
Beschreibung:Gesehen am 09.06.2023
Beschreibung:Online Resource
ISSN:2211-1247
DOI:10.1016/j.celrep.2023.112001

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