Control of centrosome distal appendages assembly and disassembly
Centrosomes are microtubule organizing centers involved in chromosome segregation, spindle orientation, cell motility and cilia formation. In recent years, they have also emerged as key modulators of asymmetric cell division. Centrosomes are composed of two centrioles that initiate duplication in S...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 April 2023
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| In: |
Cells & development
Year: 2023, Volume: 174, Pages: 1-11 |
| ISSN: | 2667-2901 |
| DOI: | 10.1016/j.cdev.2023.203839 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cdev.2023.203839 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2667290123000153 
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| Author Notes: | Johanna M.S. Streubel, Gislene Pereira |
| Summary: | Centrosomes are microtubule organizing centers involved in chromosome segregation, spindle orientation, cell motility and cilia formation. In recent years, they have also emerged as key modulators of asymmetric cell division. Centrosomes are composed of two centrioles that initiate duplication in S phase. The conservative nature of centriole duplication means that the two centrioles of a G1 cell are of different ages. They are also structurally different as only the older centriole carries appendages, an assembly of a subset of proteins primarily required for cilia formation. In a growing tissue, the non-motile, primary cilium acts as a mechano- and sensory organelle that influences cell behavior via modulation of signaling pathways. Here, we discuss the most recent findings about distal appendage composition and function, as well as cell cycle-specific regulation and their implications in various diseases. |
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| Item Description: | Online verfügbar 14. April 2023, Artikelversion 21. April 2023 Gesehen am 12.06.2023 |
| Physical Description: | Online Resource |
| ISSN: | 2667-2901 |
| DOI: | 10.1016/j.cdev.2023.203839 |