Anticholinergic burden measures, symptoms, and fall-associated risk in older adults with polypharmacy: development and validation of a prognostic model
Anticholinergic burden has been associated with adverse outcomes such as falls. To date, no gold standard measure has been identified to assess anticholinergic burden, and no conclusion has been drawn on which of the different measure algorithms best predicts falls in older patients from general pra...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 23, 2023
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| In: |
PLOS ONE
Year: 2023, Volume: 18, Issue: 1, Pages: 1-19 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0280907 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pone.0280907 Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0280907 
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| Author Notes: | Truc Sophia Dinh, Andreas D. Meid, Henrik Rudolf, Maria-Sophie Brueckle, Ana I. González-González, Veronika Bencheva, Matthias Gogolin, Kym I. E. Snell, Petra J. M. Elders, Petra A. Thuermann, Norbert Donner-Banzhoff, Jeanet W. Blom, Marjan van den Akker, Ferdinand M. Gerlach, Sebastian Harder, Ulrich Thiem, Paul P. Glasziou, Walter E. Haefeli, Christiane Muth |
MARC
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| 520 | |a Anticholinergic burden has been associated with adverse outcomes such as falls. To date, no gold standard measure has been identified to assess anticholinergic burden, and no conclusion has been drawn on which of the different measure algorithms best predicts falls in older patients from general practice. This study compared the ability of five measures of anticholinergic burden to predict falls. To account for patients’ individual susceptibility to medications, the added predictive value of typical anticholinergic symptoms was further quantified in this context. | ||
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