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Anticholinergic burden measures, symptoms, and fall-associated risk in older adults with polypharmacy: development and validation of a prognostic model

Anticholinergic burden has been associated with adverse outcomes such as falls. To date, no gold standard measure has been identified to assess anticholinergic burden, and no conclusion has been drawn on which of the different measure algorithms best predicts falls in older patients from general pra...

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Hauptverfasser: Dinh, Truc Sophia (VerfasserIn) , Meid, Andreas (VerfasserIn) , Rudolf, Henrik (VerfasserIn) , Brückle, Maria-Sophie (VerfasserIn) , González-González, Ana I. (VerfasserIn) , Bencheva, Veronika (VerfasserIn) , Gogolin, Matthias (VerfasserIn) , Snell, Kym I. E. (VerfasserIn) , Elders, Petra J. M. (VerfasserIn) , Thürmann, Petra A. (VerfasserIn) , Donner-Banzhoff, Norbert (VerfasserIn) , Blom, Jeanet W. (VerfasserIn) , Akker, Marjan van den (VerfasserIn) , Gerlach, Ferdinand M. (VerfasserIn) , Harder, Sebastian (VerfasserIn) , Thiem, Ulrich (VerfasserIn) , Glasziou, Paul (VerfasserIn) , Haefeli, Walter E. (VerfasserIn) , Muth, Christiane (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: January 23, 2023
In: PLOS ONE
Year: 2023, Jahrgang: 18, Heft: 1, Pages: 1-19
ISSN:1932-6203
DOI:10.1371/journal.pone.0280907
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pone.0280907
Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0280907
Volltext
Verfasserangaben:Truc Sophia Dinh, Andreas D. Meid, Henrik Rudolf, Maria-Sophie Brueckle, Ana I. González-González, Veronika Bencheva, Matthias Gogolin, Kym I. E. Snell, Petra J. M. Elders, Petra A. Thuermann, Norbert Donner-Banzhoff, Jeanet W. Blom, Marjan van den Akker, Ferdinand M. Gerlach, Sebastian Harder, Ulrich Thiem, Paul P. Glasziou, Walter E. Haefeli, Christiane Muth
Beschreibung
Zusammenfassung:Anticholinergic burden has been associated with adverse outcomes such as falls. To date, no gold standard measure has been identified to assess anticholinergic burden, and no conclusion has been drawn on which of the different measure algorithms best predicts falls in older patients from general practice. This study compared the ability of five measures of anticholinergic burden to predict falls. To account for patients’ individual susceptibility to medications, the added predictive value of typical anticholinergic symptoms was further quantified in this context.
Beschreibung:Gesehen am 13.12.2023
Beschreibung:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0280907

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