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Septin-3 autoimmunity in patients with paraneoplastic cerebellar ataxia

Septins are cytoskeletal proteins with filament forming capabilities, which have multiple roles during cell division, cellular polarization, morphogenesis, and membrane trafficking. Autoantibodies against septin-5 are associated with non-paraneoplastic cerebellar ataxia, and autoantibodies against s...

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Main Authors: Miske, Ramona (Author) , Scharf, Madeleine (Author) , Borowski, Kathrin (Author) , Rieckhoff, Nicole (Author) , Teegen, Bianca (Author) , Denno, Yvonne (Author) , Probst, Christian (Author) , Guthke, Kersten (Author) , Didrihsone, Ieva (Author) , Wildemann, Brigitte (Author) , Ruprecht, Klemens (Author) , Komorowski, Lars (Author) , Jarius, Sven (Author)
Format: Article (Journal)
Language:English
Published: 30 March 2023
In: Journal of neuroinflammation
Year: 2023, Volume: 20, Pages: 1-12
ISSN:1742-2094
DOI:10.1186/s12974-023-02718-9
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s12974-023-02718-9
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Author Notes:Ramona Miske, Madeleine Scharf, Kathrin Borowski, Nicole Rieckhoff, Bianca Teegen, Yvonne Denno, Christian Probst, Kersten Guthke, Ieva Didrihsone, Brigitte Wildemann, Klemens Ruprecht, Lars Komorowski and Sven Jarius

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520 |a Septins are cytoskeletal proteins with filament forming capabilities, which have multiple roles during cell division, cellular polarization, morphogenesis, and membrane trafficking. Autoantibodies against septin-5 are associated with non-paraneoplastic cerebellar ataxia, and autoantibodies against septin-7 with encephalopathy with prominent neuropsychiatric features. Here, we report on newly identified autoantibodies against septin-3 in patients with paraneoplastic cerebellar ataxia. We also propose a strategy for anti-septin autoantibody determination. 
650 4 |a Autoantibodies 
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