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Radio-resistance of hypoxic tumors: exploring the effects of oxygen and X-ray radiation on non-small lung cancer cell lines

Solid tumors are often riddled with hypoxic areas, which develops as a result of high proliferation. Cancer cells willingly adapt and thrive in hypoxia by activating complex changes which contributes to survival and enhanced resistance to treatments, such as photon radiation. Photon radiation primar...

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Main Authors: Hanley, Rachel (Author) , Pagliari, Francesca (Author) , Garcia-Calderón, Daniel (Author) , Fernandes Guerreiro, Joana (Author) , Genard, Géraldine (Author) , Jansen, Jeannette (Author) , Nisticò, Clelia (Author) , Marafioti, Maria Grazia (Author) , Tirinato, Luca (Author) , Seco, Joao (Author)
Format: Article (Journal)
Language:English
Published: 12 May 2023
In: Radiation oncology
Year: 2023, Volume: 18, Pages: 1-14
ISSN:1748-717X
DOI:10.1186/s13014-023-02275-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13014-023-02275-8
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Author Notes:Rachel Hanley, Francesca Pagliari, Daniel Garcia-Calderón, Joana Fernandes Guerreiro, Géraldine Genard, Jeannette Jansen, Clelia Nisticò, Maria Grazia Marafioti, Luca Tirinato and Joao Seco
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Summary:Solid tumors are often riddled with hypoxic areas, which develops as a result of high proliferation. Cancer cells willingly adapt and thrive in hypoxia by activating complex changes which contributes to survival and enhanced resistance to treatments, such as photon radiation. Photon radiation primarily relies on oxygen for the production of reactive oxygen species to induce DNA damage. The present in-vitro study aimed at investigating the biochemical responses of hypoxic non-small cell lung cancer (NSCLC) cells, particularly the effects on the DNA damage repair systems contributing to more radioresistant phenotypes and their pro- and anti-oxidant potential, within the first 24 h post-IR.
Item Description:Gesehen am 14.06.2023
Physical Description:Online Resource
ISSN:1748-717X
DOI:10.1186/s13014-023-02275-8

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