Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial
The metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) that the composition of the complex gut microbiome and metabolome (MIME) differ acros...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 April 2023
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| In: |
Nutrition & Diabetes
Year: 2023, Jahrgang: 13, Pages: 1-13 |
| ISSN: | 2044-4052 |
| DOI: | 10.1038/s41387-023-00235-5 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41387-023-00235-5 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41387-023-00235-5 |
| Verfasserangaben: | N. Ďásková, I. Modos, M. Krbcová, M. Kuzma, H. Pelantová, J. Hradecký, M. Heczková, M. Bratová, P. Videňská, P. Šplíchalová, M. Králová, M. Heniková, J. Potočková, A. Ouřadová, R. Landberg, T. Kühn, M. Cahová and J. Gojda |
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| 520 | |a The metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) that the composition of the complex gut microbiome and metabolome (MIME) differ across metabolic spectra (lean-obese-diabetes); (2) that specific MIME patterns could explain the differential responses to dietary inulin; and (3) that the response can be predicted based on baseline MIME signature and clinical characteristics. | ||
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