Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration
Sulfobutylether-beta-cyclodextrin (SBECD), a large cyclic oligosaccharide that is used to solubilize voriconazole (VRC) for intravenous administration, is eliminated mainly by renal excretion. The pharmacokinetics of SBECD and voriconazole in patients undergoing extracorporeal renal replacement ther...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 June 2010
|
| In: |
Antimicrobial agents and chemotherapy
Year: 2010, Volume: 54, Issue: 6, Pages: 2596-2602 |
| ISSN: | 1098-6596 |
| DOI: | 10.1128/aac.01540-09 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/aac.01540-09 Verlag, lizenzpflichtig, Volltext: https://journals.asm.org/doi/10.1128/aac.01540-09 
|
| Author Notes: | Verena Hafner, David Czock, Jürgen Burhenne, Klaus-Dieter Riedel, Jürgen Bommer, Gerd Mikus, Christoph Machleidt, Thomas Weinreich, Walter E. Haefeli |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1849819637 | ||
| 003 | DE-627 | ||
| 005 | 20230710130613.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230615s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1128/aac.01540-09 |2 doi | |
| 035 | |a (DE-627)1849819637 | ||
| 035 | |a (DE-599)KXP1849819637 | ||
| 035 | |a (OCoLC)1389793896 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hafner-Blumenstiel, Verena |e VerfasserIn |0 (DE-588)116019257X |0 (DE-627)102331570X |0 (DE-576)505539128 |4 aut | |
| 245 | 1 | 0 | |a Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration |c Verena Hafner, David Czock, Jürgen Burhenne, Klaus-Dieter Riedel, Jürgen Bommer, Gerd Mikus, Christoph Machleidt, Thomas Weinreich, Walter E. Haefeli |
| 264 | 1 | |c 1 June 2010 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.06.2023 | ||
| 520 | |a Sulfobutylether-beta-cyclodextrin (SBECD), a large cyclic oligosaccharide that is used to solubilize voriconazole (VRC) for intravenous administration, is eliminated mainly by renal excretion. The pharmacokinetics of SBECD and voriconazole in patients undergoing extracorporeal renal replacement therapies are not well defined. We performed a three-period randomized crossover study of 15 patients with end-stage renal failure during 6-hour treatment with Genius dialysis, standard hemodialysis, or hemodiafiltration using a high-flux polysulfone membrane. At the start of renal replacement therapy, the patients received a single 2-h infusion of voriconazole (4 mg per kg of body weight) solubilized with SBECD. SBECD, voriconazole, and voriconazole-N-oxide concentrations were quantified in plasma and dialysate samples by high-performance liquid chromatography (HPLC) and by HPLC coupled to tandem mass spectrometry (LC-MS-MS) and analyzed by noncompartmental methods. Nonparametric repeated-measures analysis of variance (ANOVA) was used to analyze differences between treatment phases. SBECD and voriconazole recoveries in dialysate samples were 67% and 10% of the administered doses. SBECD concentrations declined with a half-life ranging from 2.6 ± 0.6 h (Genius dialysis) to 2.4 ± 0.9 h (hemodialysis) and 2.0 ± 0.6 h (hemodiafiltration) (P < 0.01 for Genius dialysis versus hemodiafiltration). Prediction of steady-state conditions indicated that even with daily hemodialysis, SBECD will still exceed SBECD exposure of patients with normal renal function by a factor of 6.2. SBECD was effectively eliminated during 6 h of renal replacement therapy by all methods, using high-flux polysulfone membranes, whereas elimination of voriconazole was quantitatively insignificant. The SBECD half-life during renal replacement therapy was nearly normalized, but the average SBECD exposure during repeated administration is expected to be still increased. | ||
| 700 | 1 | |a Czock, David |e VerfasserIn |0 (DE-588)120971011 |0 (DE-627)705128253 |0 (DE-576)180276719 |4 aut | |
| 700 | 1 | |a Burhenne, Jürgen |d 1963- |e VerfasserIn |0 (DE-588)1034228889 |0 (DE-627)745126987 |0 (DE-576)381858197 |4 aut | |
| 700 | 1 | |a Riedel, Klaus-Dieter |e VerfasserIn |0 (DE-588)1034229605 |0 (DE-627)745128432 |0 (DE-576)381859460 |4 aut | |
| 700 | 1 | |a Bommer, Jürgen |d 1942-2022 |e VerfasserIn |0 (DE-588)1117494594 |0 (DE-627)871450372 |0 (DE-576)478997957 |4 aut | |
| 700 | 1 | |a Mikus, Gerd |e VerfasserIn |0 (DE-588)110903137 |0 (DE-627)691097941 |0 (DE-576)336988710 |4 aut | |
| 700 | 1 | |a Machleidt, Christoph |e VerfasserIn |0 (DE-588)1144183766 |0 (DE-627)1003989993 |0 (DE-576)495253340 |4 aut | |
| 700 | 1 | |a Weinreich, Thomas |e VerfasserIn |0 (DE-588)1140459554 |0 (DE-627)898480612 |0 (DE-576)493795383 |4 aut | |
| 700 | 1 | |a Haefeli, Walter E. |d 1958- |e VerfasserIn |0 (DE-588)124572359 |0 (DE-627)656806141 |0 (DE-576)340514221 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Antimicrobial agents and chemotherapy |d Washington, DC : Soc., 1972 |g 54(2010), 6, Seite 2596-2602 |h Online-Ressource |w (DE-627)306316919 |w (DE-600)1496156-8 |w (DE-576)09718859X |x 1098-6596 |7 nnas |a Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration |
| 773 | 1 | 8 | |g volume:54 |g year:2010 |g number:6 |g pages:2596-2602 |g extent:7 |a Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration |
| 856 | 4 | 0 | |u https://doi.org/10.1128/aac.01540-09 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.asm.org/doi/10.1128/aac.01540-09 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230615 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 124572359 |a Haefeli, Walter E. |m 124572359:Haefeli, Walter E. |d 910000 |d 910100 |e 910000PH124572359 |e 910100PH124572359 |k 0/910000/ |k 1/910000/910100/ |p 9 |y j | ||
| 998 | |g 110903137 |a Mikus, Gerd |m 110903137:Mikus, Gerd |d 910000 |d 910100 |e 910000PM110903137 |e 910100PM110903137 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 1117494594 |a Bommer, Jürgen |m 1117494594:Bommer, Jürgen |p 5 | ||
| 998 | |g 1034229605 |a Riedel, Klaus-Dieter |m 1034229605:Riedel, Klaus-Dieter |d 910000 |d 910100 |e 910000PR1034229605 |e 910100PR1034229605 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1034228889 |a Burhenne, Jürgen |m 1034228889:Burhenne, Jürgen |d 910000 |d 910100 |e 910000PB1034228889 |e 910100PB1034228889 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 120971011 |a Czock, David |m 120971011:Czock, David |d 910000 |d 910100 |e 910000PC120971011 |e 910100PC120971011 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 116019257X |a Hafner-Blumenstiel, Verena |m 116019257X:Hafner-Blumenstiel, Verena |p 1 |x j | ||
| 999 | |a KXP-PPN1849819637 |e 4338801662 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"7 S."}],"language":["eng"],"name":{"displayForm":["Verena Hafner, David Czock, Jürgen Burhenne, Klaus-Dieter Riedel, Jürgen Bommer, Gerd Mikus, Christoph Machleidt, Thomas Weinreich, Walter E. Haefeli"]},"person":[{"display":"Hafner-Blumenstiel, Verena","role":"aut","roleDisplay":"VerfasserIn","given":"Verena","family":"Hafner-Blumenstiel"},{"display":"Czock, David","given":"David","role":"aut","roleDisplay":"VerfasserIn","family":"Czock"},{"display":"Burhenne, Jürgen","role":"aut","roleDisplay":"VerfasserIn","given":"Jürgen","family":"Burhenne"},{"display":"Riedel, Klaus-Dieter","role":"aut","roleDisplay":"VerfasserIn","given":"Klaus-Dieter","family":"Riedel"},{"family":"Bommer","given":"Jürgen","role":"aut","roleDisplay":"VerfasserIn","display":"Bommer, Jürgen"},{"family":"Mikus","given":"Gerd","roleDisplay":"VerfasserIn","role":"aut","display":"Mikus, Gerd"},{"given":"Christoph","roleDisplay":"VerfasserIn","role":"aut","family":"Machleidt","display":"Machleidt, Christoph"},{"family":"Weinreich","role":"aut","roleDisplay":"VerfasserIn","given":"Thomas","display":"Weinreich, Thomas"},{"family":"Haefeli","role":"aut","roleDisplay":"VerfasserIn","given":"Walter E.","display":"Haefeli, Walter E."}],"id":{"eki":["1849819637"],"doi":["10.1128/aac.01540-09"]},"title":[{"title":"Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration","title_sort":"Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration"}],"origin":[{"dateIssuedDisp":"1 June 2010","dateIssuedKey":"2010"}],"relHost":[{"name":{"displayForm":["publ. by the American Society for Microbiology"]},"origin":[{"publisher":"Soc.","dateIssuedDisp":"1972-","dateIssuedKey":"1972","publisherPlace":"Washington, DC"}],"id":{"zdb":["1496156-8"],"eki":["306316919"],"issn":["1098-6596"]},"title":[{"subtitle":"AAC","title_sort":"Antimicrobial agents and chemotherapy","title":"Antimicrobial agents and chemotherapy"}],"recId":"306316919","note":["Gesehen am 09.06.21"],"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"American Society for Microbiology"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"AAC"}],"pubHistory":["1.1972 -"],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltrationAntimicrobial agents and chemotherapy","part":{"extent":"7","volume":"54","issue":"6","text":"54(2010), 6, Seite 2596-2602","year":"2010","pages":"2596-2602"},"language":["eng"]}],"recId":"1849819637","note":["Gesehen am 15.06.2023"]} | ||
| SRT | |a HAFNERBLUMPHARMACOKI1201 | ||