Apparent bias for P. falciparum parasites carrying the wild-type pfcrt allele in the placenta
Resistance to chloroquine has been linked to polymorphisms within the pfcrt gene of the human malarial parasite Plasmodium falciparum. Here, we have investigated the prevalence of the pfcrt allele associated with chloroquine resistance in the peripheral blood and the placenta of pregnant women diagn...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 February 2010
|
| In: |
Parasitology research
Year: 2010, Volume: 106, Issue: 5, Pages: 1065-1070 |
| ISSN: | 1432-1955 |
| DOI: | 10.1007/s00436-010-1756-7 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00436-010-1756-7
|
| Author Notes: | Nadja Oster, Petra Rohrbach, Cecilia P. Sanchez, Katharine T. Andrews, Judith Kammer, Boubacar Coulibaly, Gabriele Stieglbauer, Heiko Becher, Michael Lanzer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1850504970 | ||
| 003 | DE-627 | ||
| 005 | 20231113113445.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230619s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00436-010-1756-7 |2 doi | |
| 035 | |a (DE-627)1850504970 | ||
| 035 | |a (DE-599)KXP1850504970 | ||
| 035 | |a (OCoLC)1389794032 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Oster, Nadja |d 1971- |e VerfasserIn |0 (DE-588)121700232 |0 (DE-627)705621774 |0 (DE-576)181522799 |4 aut | |
| 245 | 1 | 0 | |a Apparent bias for P. falciparum parasites carrying the wild-type pfcrt allele in the placenta |c Nadja Oster, Petra Rohrbach, Cecilia P. Sanchez, Katharine T. Andrews, Judith Kammer, Boubacar Coulibaly, Gabriele Stieglbauer, Heiko Becher, Michael Lanzer |
| 264 | 1 | |c 11 February 2010 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.06.2023 | ||
| 520 | |a Resistance to chloroquine has been linked to polymorphisms within the pfcrt gene of the human malarial parasite Plasmodium falciparum. Here, we have investigated the prevalence of the pfcrt allele associated with chloroquine resistance in the peripheral blood and the placenta of pregnant women diagnosed with a P. falciparum infection. Our molecular epidemiological data show an unequal distribution with a significant under-representation of parasites carrying the mutated pfcrt allele in the placenta, as compared to the peripheral blood. In comparison, no differences were seen with regard to pfmdr1 polymorphisms of these parasites. Our data suggest a selective disadvantage of the polymorphic and a selective advantage of the wild-type pfcrt haplotype in the placenta, supporting the model that the human host provides various microenvironments that favor genetically distinct P. falciparum populations. | ||
| 650 | 4 | |a Chloroquine | |
| 650 | 4 | |a Chloroquine Resistance | |
| 650 | 4 | |a Malaria | |
| 650 | 4 | |a Parasite Population | |
| 650 | 4 | |a Placental Sample | |
| 700 | 1 | |a Rohrbach, Petra |e VerfasserIn |0 (DE-588)1309122342 |0 (DE-627)1869720970 |4 aut | |
| 700 | 1 | |a Sanchez, Cecilia P. |e VerfasserIn |0 (DE-588)1079241388 |0 (DE-627)840669348 |0 (DE-576)452286093 |4 aut | |
| 700 | 1 | |a Andrews, Katharine T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kammer, Judith |e VerfasserIn |4 aut | |
| 700 | 1 | |a Coulibaly, Boubacar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stieglbauer, Gabriele |e VerfasserIn |0 (DE-588)1127587285 |0 (DE-627)882020501 |0 (DE-576)485275589 |4 aut | |
| 700 | 1 | |a Becher, Heiko |e VerfasserIn |0 (DE-588)1027740677 |0 (DE-627)729629260 |0 (DE-576)375063439 |4 aut | |
| 700 | 1 | |a Lanzer, Michael |e VerfasserIn |0 (DE-588)1065643314 |0 (DE-627)816506736 |0 (DE-576)165563826 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Parasitology research |d Berlin : Springer, 1987 |g 106(2010), 5, Seite 1065-1070 |h Online-Ressource |w (DE-627)254638627 |w (DE-600)1462976-8 |w (DE-576)074531565 |x 1432-1955 |7 nnas |a Apparent bias for P. falciparum parasites carrying the wild-type pfcrt allele in the placenta |
| 773 | 1 | 8 | |g volume:106 |g year:2010 |g number:5 |g pages:1065-1070 |g extent:6 |a Apparent bias for P. falciparum parasites carrying the wild-type pfcrt allele in the placenta |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00436-010-1756-7 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230619 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1065643314 |a Lanzer, Michael |m 1065643314:Lanzer, Michael |d 910000 |d 911700 |e 910000PL1065643314 |e 911700PL1065643314 |k 0/910000/ |k 1/910000/911700/ |p 9 |y j | ||
| 998 | |g 1027740677 |a Becher, Heiko |m 1027740677:Becher, Heiko |d 910000 |d 911700 |e 910000PB1027740677 |e 911700PB1027740677 |k 0/910000/ |k 1/910000/911700/ |p 8 | ||
| 998 | |g 1127587285 |a Stieglbauer, Gabriele |m 1127587285:Stieglbauer, Gabriele |d 50000 |e 50000PS1127587285 |k 0/50000/ |p 7 | ||
| 998 | |g 1079241388 |a Sanchez, Cecilia P. |m 1079241388:Sanchez, Cecilia P. |d 910000 |d 911700 |d 50000 |e 910000PS1079241388 |e 911700PS1079241388 |e 50000PS1079241388 |k 0/910000/ |k 1/910000/911700/ |k 0/50000/ |p 3 | ||
| 998 | |g 121700232 |a Oster, Nadja |m 121700232:Oster, Nadja |p 1 |x j | ||
| 999 | |a KXP-PPN1850504970 |e 4340326186 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"6 S."}],"person":[{"given":"Nadja","family":"Oster","role":"aut","display":"Oster, Nadja"},{"given":"Petra","family":"Rohrbach","role":"aut","display":"Rohrbach, Petra"},{"given":"Cecilia P.","family":"Sanchez","display":"Sanchez, Cecilia P.","role":"aut"},{"display":"Andrews, Katharine T.","role":"aut","family":"Andrews","given":"Katharine T."},{"given":"Judith","family":"Kammer","role":"aut","display":"Kammer, Judith"},{"role":"aut","display":"Coulibaly, Boubacar","given":"Boubacar","family":"Coulibaly"},{"role":"aut","display":"Stieglbauer, Gabriele","given":"Gabriele","family":"Stieglbauer"},{"family":"Becher","given":"Heiko","display":"Becher, Heiko","role":"aut"},{"display":"Lanzer, Michael","role":"aut","family":"Lanzer","given":"Michael"}],"title":[{"title":"Apparent bias for P. falciparum parasites carrying the wild-type pfcrt allele in the placenta","title_sort":"Apparent bias for P. falciparum parasites carrying the wild-type pfcrt allele in the placenta"}],"relHost":[{"title":[{"subtitle":"founded as Zeitschrift für Parasitenkunde","title_sort":"Parasitology research","title":"Parasitology research"}],"part":{"year":"2010","volume":"106","extent":"6","text":"106(2010), 5, Seite 1065-1070","pages":"1065-1070","issue":"5"},"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Apparent bias for P. falciparum parasites carrying the wild-type pfcrt allele in the placentaParasitology research","language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 27.01.25","Fortsetzung der Druck-Ausgabe"],"origin":[{"publisherPlace":"Berlin ; Heidelberg ; Berlin ; Heidelberg ; New York, NY","dateIssuedKey":"1987","publisher":"Springer ; Springer","dateIssuedDisp":"1987-"}],"id":{"issn":["1432-1955"],"eki":["254638627"],"zdb":["1462976-8"]},"pubHistory":["Volume 73, issue 1 (January 1987)-"],"recId":"254638627"}],"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"11 February 2010"}],"note":["Gesehen am 19.06.2023"],"id":{"doi":["10.1007/s00436-010-1756-7"],"eki":["1850504970"]},"name":{"displayForm":["Nadja Oster, Petra Rohrbach, Cecilia P. Sanchez, Katharine T. Andrews, Judith Kammer, Boubacar Coulibaly, Gabriele Stieglbauer, Heiko Becher, Michael Lanzer"]},"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1850504970"} | ||
| SRT | |a OSTERNADJAAPPARENTBI1120 | ||