Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody
Using a transgenic mouse model of ischemic stroke we checked for a possible interaction of antiphospholipid antibodies (aPL) which often cause thromboses as well as central nervous system (CNS) involvement under non-thrombotic conditions and the TWEAK/Fn14 pathway known to be adversely involved in i...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
25 May 2010
|
| In: |
Journal of neuroimmunology
Year: 2010, Jahrgang: 227, Heft: 1-2, Pages: 1-9 |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/j.jneuroim.2010.05.043 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jneuroim.2010.05.043 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165572810002523 
|
| Verfasserangaben: | Katrin Frauenknecht, Panagiotis Bargiotas, Henrike Bauer, Philipp von Landenberg, Markus Schwaninger, Clemens Sommer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1850511969 | ||
| 003 | DE-627 | ||
| 005 | 20230710130234.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230619s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jneuroim.2010.05.043 |2 doi | |
| 035 | |a (DE-627)1850511969 | ||
| 035 | |a (DE-599)KXP1850511969 | ||
| 035 | |a (OCoLC)1389794043 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Frauenknecht, Katrin Barbara Magda |d 1977- |e VerfasserIn |0 (DE-588)134060679 |0 (DE-627)560208731 |0 (DE-576)300285388 |4 aut | |
| 245 | 1 | 0 | |a Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody |c Katrin Frauenknecht, Panagiotis Bargiotas, Henrike Bauer, Philipp von Landenberg, Markus Schwaninger, Clemens Sommer |
| 264 | 1 | |c 25 May 2010 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.06.2023 | ||
| 520 | |a Using a transgenic mouse model of ischemic stroke we checked for a possible interaction of antiphospholipid antibodies (aPL) which often cause thromboses as well as central nervous system (CNS) involvement under non-thrombotic conditions and the TWEAK/Fn14 pathway known to be adversely involved in inflammatory and ischemic brain disease. After 7days, infarct volumes were reduced in Fn14 deficient mice and were further decreased by aPL treatment. This was associated with strongest increase of the endogenous neuroprotective G-CSF/G-CSF receptor system. This unexpected beneficial action of aPL is an example for a non-thrombogenic action and the double-edged nature of aPL. | ||
| 650 | 4 | |a Antiphospholipid antibodies | |
| 650 | 4 | |a Antiphospholipid syndrome | |
| 650 | 4 | |a Fn14 | |
| 650 | 4 | |a Granulocyte-colony stimulating factor | |
| 650 | 4 | |a Neuroprotection | |
| 650 | 4 | |a Stroke | |
| 700 | 1 | |a Bargiotas, Panagiotis |d 1981- |e VerfasserIn |0 (DE-588)1028373899 |0 (DE-627)730621898 |0 (DE-576)375908234 |4 aut | |
| 700 | 1 | |a Bauer, Henrike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Landenberg, Philipp von |e VerfasserIn |0 (DE-588)114739285 |0 (DE-627)077182375 |0 (DE-576)289806941 |4 aut | |
| 700 | 1 | |a Schwaninger, Markus |e VerfasserIn |0 (DE-588)1028374909 |0 (DE-627)730623939 |0 (DE-576)375910174 |4 aut | |
| 700 | 1 | |a Sommer, Clemens |d 1964- |e VerfasserIn |0 (DE-588)1070862185 |0 (DE-627)824644514 |0 (DE-576)432763996 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuroimmunology |d Amsterdam [u.a.] : Elsevier Science, 1981 |g 227(2010), 1-2, Seite 1-9 |h Online-Ressource |w (DE-627)306659778 |w (DE-600)1500497-1 |w (DE-576)081986408 |x 1872-8421 |7 nnas |a Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody |
| 773 | 1 | 8 | |g volume:227 |g year:2010 |g number:1-2 |g pages:1-9 |g extent:9 |a Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jneuroim.2010.05.043 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0165572810002523 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230619 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1028374909 |a Schwaninger, Markus |m 1028374909:Schwaninger, Markus |d 50000 |d 54600 |e 50000PS1028374909 |e 54600PS1028374909 |k 0/50000/ |k 1/50000/54600/ |p 5 | ||
| 998 | |g 1028373899 |a Bargiotas, Panagiotis |m 1028373899:Bargiotas, Panagiotis |d 50000 |d 54600 |e 50000PB1028373899 |e 54600PB1028373899 |k 0/50000/ |k 1/50000/54600/ |p 2 | ||
| 999 | |a KXP-PPN1850511969 |e 4340372064 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1850511969","relHost":[{"language":["eng"],"id":{"issn":["1872-8421"],"eki":["306659778"],"zdb":["1500497-1"]},"pubHistory":["1.1981 -"],"note":["Gesehen am 19.02.20","Ungezählte Beil.: Supplement"],"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1981","dateIssuedDisp":"1981-","publisher":"Elsevier Science"}],"recId":"306659778","type":{"media":"Online-Ressource","bibl":"periodical"},"physDesc":[{"extent":"Online-Ressource"}],"disp":"Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibodyJournal of neuroimmunology","part":{"text":"227(2010), 1-2, Seite 1-9","year":"2010","pages":"1-9","issue":"1-2","volume":"227","extent":"9"},"title":[{"subtitle":"official journal of the International Society for Neuroimmunology","title_sort":"Journal of neuroimmunology","title":"Journal of neuroimmunology"}]}],"origin":[{"dateIssuedDisp":"25 May 2010","dateIssuedKey":"2010"}],"note":["Gesehen am 19.06.2023"],"title":[{"title":"Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody","title_sort":"Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody"}],"person":[{"role":"aut","display":"Frauenknecht, Katrin Barbara Magda","given":"Katrin Barbara Magda","family":"Frauenknecht"},{"role":"aut","given":"Panagiotis","display":"Bargiotas, Panagiotis","family":"Bargiotas"},{"family":"Bauer","display":"Bauer, Henrike","given":"Henrike","role":"aut"},{"role":"aut","display":"Landenberg, Philipp von","given":"Philipp von","family":"Landenberg"},{"family":"Schwaninger","given":"Markus","display":"Schwaninger, Markus","role":"aut"},{"display":"Sommer, Clemens","given":"Clemens","role":"aut","family":"Sommer"}],"id":{"doi":["10.1016/j.jneuroim.2010.05.043"],"eki":["1850511969"]},"physDesc":[{"extent":"9 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Katrin Frauenknecht, Panagiotis Bargiotas, Henrike Bauer, Philipp von Landenberg, Markus Schwaninger, Clemens Sommer"]},"language":["eng"]} | ||
| SRT | |a FRAUENKNECNEUROPROTE2520 | ||