Structure, dynamics, and energetics of siRNA−cationic vector complexation: a molecular dynamics study

The design and synthesis of safe and efficient nonviral vectors for gene delivery has attracted significant attention in recent years. Previous experiments have revealed that the charge density of a polycation (the carrier) plays a crucial role in complexation and the release of the gene from the co...

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Bibliographische Detailangaben

Hauptverfasser:	Ouyang, Defang (VerfasserIn) , Zhang, Hong (VerfasserIn) , Herten, Dirk-Peter (VerfasserIn) , Parekh, Harendra S. (VerfasserIn) , Smith, Sean C. (VerfasserIn)
Dokumenttyp:	Article (Journal)
Sprache:	Englisch
Veröffentlicht:	June 28, 2010
In:	The journal of physical chemistry. B, Biophysics, biomaterials, liquids, and soft matter Year: 2010, Jahrgang: 114, Heft: 28, Pages: 9220-9230
ISSN:	1520-5207
DOI:	10.1021/jp911906e
Online-Zugang:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/jp911906e
Verfasserangaben:	Defang Ouyang, Hong Zhang, Dirk-Peter Herten, Harendra S. Parekh, and Sean C. Smith