Lipid based therapy for ulcerative colitis: modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation
Ulcerative colitis (UC) is the result of an inappropriate colonic inflammatory response triggered by environmental and genetic factors. We have recently shown that mucus from UC patients has a decreased phosphatidylcholine (PC) content, while clinical trials revealed that therapeutic addition of PC...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 October 2010
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| In: |
International journal of molecular sciences
Year: 2010, Volume: 11, Issue: 10, Pages: 4149-4164 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms11104149 |
| Online Access: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.3390/ijms11104149 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/11/10/4149 |
| Author Notes: | Hannah Schneider, Annika Braun, Joachim Füllekrug, Wolfgang Stremmel and Robert Ehehalt |
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| 520 | |a Ulcerative colitis (UC) is the result of an inappropriate colonic inflammatory response triggered by environmental and genetic factors. We have recently shown that mucus from UC patients has a decreased phosphatidylcholine (PC) content, while clinical trials revealed that therapeutic addition of PC to the colonic mucus alleviated the inflammatory activity. The mechanisms behind this are still unclear. | ||
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