Mini-review: the neurobiology of treating substance use disorders with classical psychedelics
The potential of psychedelics to persistently treat substance use disorders is known since the 1960s. However, the biological mechanisms responsible for their therapeutic effects have not yet been fully elucidated. While it is known that serotonergic hallucinogens induce changes in gene expression a...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 April 2023
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| In: |
Frontiers in neuroscience
Year: 2023, Volume: 17, Pages: 1-9 |
| ISSN: | 1662-453X |
| DOI: | 10.3389/fnins.2023.1156319 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fnins.2023.1156319 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fnins.2023.1156319/full 
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| Author Notes: | Marvin M. Urban, Moritz R. Stingl and Marcus W. Meinhardt |
| Summary: | The potential of psychedelics to persistently treat substance use disorders is known since the 1960s. However, the biological mechanisms responsible for their therapeutic effects have not yet been fully elucidated. While it is known that serotonergic hallucinogens induce changes in gene expression and neuroplasticity, particularly in prefrontal regions, theories on how specifically this counteracts the alterations that occur in neuronal circuitry throughout the course of addiction are largely unknown. This narrative mini-review endeavors to synthesize well-established knowledge from addiction research with findings and theories regarding the neurobiological effects of psychedelics to give an overview of the potential mechanisms that underlie the treatment of substance use disorders with classical hallucinogenic compounds and point out gaps in the current understanding. |
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| Item Description: | Gesehen am 20.06.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1662-453X |
| DOI: | 10.3389/fnins.2023.1156319 |