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Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth

Precise organization of growing structures is a fundamental process in developmental biology. In plants, radial growth is mediated by the cambium, a stem cell niche continuously producing wood (xylem) and bast (phloem) in a strictly bidirectional manner. While this process contributes large parts to...

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Hauptverfasser: Lebovka, Ivan (VerfasserIn) , Hay Mele, Bruno (VerfasserIn) , Liu, Xiaomin (VerfasserIn) , Zakieva, Alexandra (VerfasserIn) , Schlamp, Theresa (VerfasserIn) , Gursanscky, Nial Rau (VerfasserIn) , Merks, Roeland MH (VerfasserIn) , Großeholz, Ruth (VerfasserIn) , Greb, Thomas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 March 2023
In: eLife
Year: 2023, Jahrgang: 12, Pages: 1-37
ISSN:2050-084X
DOI:10.7554/eLife.66627
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.66627
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Verfasserangaben:Ivan Lebovka, Bruno Hay Mele, Xiaomin Liu, Alexandra Zakieva, Theresa Schlamp, Nial Rau Gursanscky, Roeland MH Merks, Ruth Großeholz, Thomas Greb
Beschreibung
Zusammenfassung:Precise organization of growing structures is a fundamental process in developmental biology. In plants, radial growth is mediated by the cambium, a stem cell niche continuously producing wood (xylem) and bast (phloem) in a strictly bidirectional manner. While this process contributes large parts to terrestrial biomass, cambium dynamics eludes direct experimental access due to obstacles in live-cell imaging. Here, we present a cell-based computational model visualizing cambium activity and integrating the function of central cambium regulators. Performing iterative comparisons of plant and model anatomies, we conclude that the receptor-like kinase PXY and its ligand CLE41 are part of a minimal framework sufficient for instructing tissue organization. By integrating tissue-specific cell wall stiffness values, we moreover probe the influence of physical constraints on tissue geometry. Our model highlights the role of intercellular communication within the cambium and shows that a limited number of factors are sufficient to create radial growth by bidirectional tissue production.
Beschreibung:Gesehen am 21.06.2023
Beschreibung:Online Resource
ISSN:2050-084X
DOI:10.7554/eLife.66627

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