Implementation of whole-genome and transcriptome sequencing into clinical cancer care
PURPOSE - - The combination of whole-genome and transcriptome sequencing (WGTS) is expected to transform diagnosis and treatment for patients with cancer. WGTS is a comprehensive precision diagnostic test that is starting to replace the standard of care for oncology molecular testing in health care...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 8, 2022
|
| In: |
JCO precision oncology
Year: 2022, Jahrgang: 6, Pages: 1-11 |
| ISSN: | 2473-4284 |
| DOI: | 10.1200/PO.22.00245 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1200/PO.22.00245 Verlag, lizenzpflichtig, Volltext: https://ascopubs.org/doi/10.1200/PO.22.00245 
|
| Verfasserangaben: | Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Åke Levin, Charles G. Mullighan, Reinhard Buettner, Trevor J. Pugh, Sean Grimmond, Carlos Caldas, Fabrice Andre, Ilse Custers, Elias Campo, Hans van Snellenberg, Anna Schuh, Hidewaki Nakagawa, Christof von Kalle, Torsten Haferlach, Stefan Fröhling, and Vaidehi Jobanputra |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1850981450 | ||
| 003 | DE-627 | ||
| 005 | 20240807083150.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230626s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1200/PO.22.00245 |2 doi | |
| 035 | |a (DE-627)1850981450 | ||
| 035 | |a (DE-599)KXP1850981450 | ||
| 035 | |a (OCoLC)1389533496 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Cuppen, Edwin |d 1970- |e VerfasserIn |0 (DE-588)173304982 |0 (DE-627)698222520 |0 (DE-576)134153189 |4 aut | |
| 245 | 1 | 0 | |a Implementation of whole-genome and transcriptome sequencing into clinical cancer care |c Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Åke Levin, Charles G. Mullighan, Reinhard Buettner, Trevor J. Pugh, Sean Grimmond, Carlos Caldas, Fabrice Andre, Ilse Custers, Elias Campo, Hans van Snellenberg, Anna Schuh, Hidewaki Nakagawa, Christof von Kalle, Torsten Haferlach, Stefan Fröhling, and Vaidehi Jobanputra |
| 264 | 1 | |c December 8, 2022 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.06.2023 | ||
| 520 | |a PURPOSE - - The combination of whole-genome and transcriptome sequencing (WGTS) is expected to transform diagnosis and treatment for patients with cancer. WGTS is a comprehensive precision diagnostic test that is starting to replace the standard of care for oncology molecular testing in health care systems around the world; however, the implementation and widescale adoption of this best-in-class testing is lacking. - - METHODS - - Here, we address the barriers in integrating WGTS for cancer diagnostics and treatment selection and answer questions regarding utility in different cancer types, cost-effectiveness and affordability, and other practical considerations for WGTS implementation. - - RESULTS - - We review the current studies implementing WGTS in health care systems and provide a synopsis of the clinical evidence and insights into practical considerations for WGTS implementation. We reflect on regulatory, costs, reimbursement, and incidental findings aspects of this test. - - CONCLUSION - - WGTS is an appropriate comprehensive clinical test for many tumor types and can replace multiple, cascade testing approaches currently performed. Decreasing sequencing cost, increasing number of clinically relevant aberrations and discovery of more complex biomarkers of treatment response, should pave the way for health care systems and laboratories in implementing WGTS into clinical practice, to transform diagnosis and treatment for patients with cancer. | ||
| 700 | 1 | |a Elemento, Olivier |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rosenquist, Richard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nikic, Svetlana |e VerfasserIn |4 aut | |
| 700 | 1 | |a IJzerman, Maarten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zaleski, Isabelle Durand |e VerfasserIn |4 aut | |
| 700 | 1 | |a Frederix, Geert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Levin, Lars-Åke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mullighan, Charles G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Buettner, Reinhard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pugh, Trevor J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grimmond, Sean |e VerfasserIn |4 aut | |
| 700 | 1 | |a Caldas, Carlos |e VerfasserIn |4 aut | |
| 700 | 1 | |a Andre, Fabrice |e VerfasserIn |4 aut | |
| 700 | 1 | |a Custers, Ilse |e VerfasserIn |4 aut | |
| 700 | 1 | |a Campo, Elias |e VerfasserIn |4 aut | |
| 700 | 1 | |a van Snellenberg, Hans |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schuh, Anna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nakagawa, Hidewaki |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kalle, Christof von |d 1962- |e VerfasserIn |0 (DE-588)1036481115 |0 (DE-627)75107926X |0 (DE-576)168957396 |4 aut | |
| 700 | 1 | |a Haferlach, Torsten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fröhling, Stefan |d 1969- |e VerfasserIn |0 (DE-588)120890046 |0 (DE-627)080950302 |0 (DE-576)188733930 |4 aut | |
| 700 | 1 | |a Jobanputra, Vaidehi |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t JCO precision oncology |d Alexandria, VA : American Society of Clinical Oncology, 2017 |g 6(2022) vom: Dez., Artikel-ID e2200245, Seite 1-11 |h Online-Ressource |w (DE-627)1067396667 |w (DE-600)2964799-X |w (DE-576)518266486 |x 2473-4284 |7 nnas |a Implementation of whole-genome and transcriptome sequencing into clinical cancer care |
| 773 | 1 | 8 | |g volume:6 |g year:2022 |g month:12 |g elocationid:e2200245 |g pages:1-11 |g extent:11 |a Implementation of whole-genome and transcriptome sequencing into clinical cancer care |
| 856 | 4 | 0 | |u https://doi.org/10.1200/PO.22.00245 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://ascopubs.org/doi/10.1200/PO.22.00245 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230626 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 120890046 |a Fröhling, Stefan |m 120890046:Fröhling, Stefan |d 50000 |e 50000PF120890046 |k 0/50000/ |p 22 | ||
| 998 | |g 1036481115 |a Kalle, Christof von |m 1036481115:Kalle, Christof von |d 50000 |e 50000PK1036481115 |k 0/50000/ |p 20 | ||
| 999 | |a KXP-PPN1850981450 |e 4343632326 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1200/PO.22.00245"],"eki":["1850981450"]},"physDesc":[{"extent":"11 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Implementation of whole-genome and transcriptome sequencing into clinical cancer care","title":"Implementation of whole-genome and transcriptome sequencing into clinical cancer care"}],"origin":[{"dateIssuedDisp":"December 8, 2022","dateIssuedKey":"2022"}],"relHost":[{"language":["eng"],"part":{"volume":"6","year":"2022","pages":"1-11","extent":"11","text":"6(2022) vom: Dez., Artikel-ID e2200245, Seite 1-11"},"pubHistory":["Volume 1 (2017)-"],"note":["Gesehen am 06.07.21"],"disp":"Implementation of whole-genome and transcriptome sequencing into clinical cancer careJCO precision oncology","type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"JCO PO"}],"recId":"1067396667","title":[{"subtitle":"an American Society of Clinical Oncology journal","title":"JCO precision oncology","title_sort":"JCO precision oncology"}],"id":{"issn":["2473-4284"],"eki":["1067396667"],"zdb":["2964799-X"]},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisher":"American Society of Clinical Oncology","dateIssuedDisp":"2017-","dateIssuedKey":"2017","publisherPlace":"Alexandria, VA"}]}],"language":["eng"],"name":{"displayForm":["Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Åke Levin, Charles G. Mullighan, Reinhard Buettner, Trevor J. Pugh, Sean Grimmond, Carlos Caldas, Fabrice Andre, Ilse Custers, Elias Campo, Hans van Snellenberg, Anna Schuh, Hidewaki Nakagawa, Christof von Kalle, Torsten Haferlach, Stefan Fröhling, and Vaidehi Jobanputra"]},"note":["Gesehen am 26.06.2023"],"person":[{"given":"Edwin","display":"Cuppen, Edwin","role":"aut","family":"Cuppen"},{"given":"Olivier","display":"Elemento, Olivier","family":"Elemento","role":"aut"},{"family":"Rosenquist","role":"aut","given":"Richard","display":"Rosenquist, Richard"},{"given":"Svetlana","display":"Nikic, Svetlana","role":"aut","family":"Nikic"},{"role":"aut","family":"IJzerman","display":"IJzerman, Maarten","given":"Maarten"},{"role":"aut","family":"Zaleski","display":"Zaleski, Isabelle Durand","given":"Isabelle Durand"},{"family":"Frederix","role":"aut","given":"Geert","display":"Frederix, Geert"},{"display":"Levin, Lars-Åke","given":"Lars-Åke","family":"Levin","role":"aut"},{"role":"aut","family":"Mullighan","display":"Mullighan, Charles G.","given":"Charles G."},{"display":"Buettner, Reinhard","given":"Reinhard","family":"Buettner","role":"aut"},{"family":"Pugh","role":"aut","display":"Pugh, Trevor J.","given":"Trevor J."},{"given":"Sean","display":"Grimmond, Sean","family":"Grimmond","role":"aut"},{"given":"Carlos","display":"Caldas, Carlos","role":"aut","family":"Caldas"},{"role":"aut","family":"Andre","display":"Andre, Fabrice","given":"Fabrice"},{"given":"Ilse","display":"Custers, Ilse","family":"Custers","role":"aut"},{"display":"Campo, Elias","given":"Elias","role":"aut","family":"Campo"},{"role":"aut","family":"van Snellenberg","display":"van Snellenberg, Hans","given":"Hans"},{"display":"Schuh, Anna","given":"Anna","family":"Schuh","role":"aut"},{"display":"Nakagawa, Hidewaki","given":"Hidewaki","family":"Nakagawa","role":"aut"},{"display":"Kalle, Christof von","given":"Christof von","role":"aut","family":"Kalle"},{"display":"Haferlach, Torsten","given":"Torsten","family":"Haferlach","role":"aut"},{"role":"aut","family":"Fröhling","given":"Stefan","display":"Fröhling, Stefan"},{"role":"aut","family":"Jobanputra","given":"Vaidehi","display":"Jobanputra, Vaidehi"}],"recId":"1850981450"} | ||
| SRT | |a CUPPENEDWIIMPLEMENTA8202 | ||