An unbiased genome-wide analysis of zinc-finger nuclease specificity
Zinc-finger nucleases allow targeted genetic modification at loci chosen by the investigator, but the extent of their off-target activity—which could be toxic to cells—has not been evaluated experimentally on a genome-wide scale. Gabriel et al. document the off- and on-target activity of zinc-finger...
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 August 2011
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| In: |
Nature biotechnology
Year: 2011, Jahrgang: 29, Heft: 9, Pages: 816-823 |
| ISSN: | 1546-1696 |
| DOI: | 10.1038/nbt.1948 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nbt.1948 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nbt.1948 
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| Verfasserangaben: | Richard Gabriel, Angelo Lombardo, Anne Arens, Jeffrey C. Miller, Pietro Genovese, Christine Kaeppel, Ali Nowrouzi, Cynthia C. Bartholomae, Jianbin Wang, Geoffrey Friedman, Michael C. Holmes, Philip D. Gregory, Hanno Glimm, Manfred Schmidt, Luigi Naldini & Christof von Kalle |
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| 520 | |a Zinc-finger nucleases allow targeted genetic modification at loci chosen by the investigator, but the extent of their off-target activity—which could be toxic to cells—has not been evaluated experimentally on a genome-wide scale. Gabriel et al. document the off- and on-target activity of zinc-finger nucleases using lentiviral vectors to tag integration sites. | ||
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