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ΔNp73β is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria

p73 belongs to the p53 family of transcription factors known to regulate cell cycle and apoptosis. The Trp73 gene has two promoters that drive the expression of two major p73 isoform subfamilies: TA and ΔN. In general, TAp73 isoforms show proapoptotic activities, whereas members of the N-terminally...

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Hauptverfasser: Schuster, André (VerfasserIn) , Schilling, Tobias (VerfasserIn) , De Laurenzi, Vincenzo (VerfasserIn) , Koch, Andreas Franz (VerfasserIn) , Seitz, Sarah Janina (VerfasserIn) , Staib, Frank (VerfasserIn) , Teufel, Andreas (VerfasserIn) , Thorgeirsson, Snorri S. (VerfasserIn) , Galle, Peter (VerfasserIn) , Melino, Gerry (VerfasserIn) , Stremmel, Wolfgang (VerfasserIn) , Krammer, Peter H. (VerfasserIn) , Müller-Schilling, Martina (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 01 Jul 2010
In: Cell cycle
Year: 2010, Jahrgang: 9, Heft: 13, Pages: 2629-2639
ISSN:1551-4005
DOI:10.4161/cc.9.13.12110
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.4161/cc.9.13.12110
Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/abs/10.4161/cc.9.13.12110
Volltext
Verfasserangaben:André Schuster, Tobias Schilling, Vincenzo De Laurenzi, Andreas F. Koch, Sarah Seitz, Frank Staib, Andreas Teufel, Snorri S. Thorgeirsson, Peter Galle, Gerry Melino, Wolfgang Stremmel, Peter H. Krammer & Martina Müller
Beschreibung
Zusammenfassung:p73 belongs to the p53 family of transcription factors known to regulate cell cycle and apoptosis. The Trp73 gene has two promoters that drive the expression of two major p73 isoform subfamilies: TA and ΔN. In general, TAp73 isoforms show proapoptotic activities, whereas members of the N-terminally truncated (ΔN) p73 subfamily that lack the transactivation domain show antiapoptotic functions. We found that upregulation of ΔNp73 in hepatocellular carcinoma (HCC) correlated with reduced survival. Here, we investigated the molecular mechanisms accounting for the oncogenic role of ΔNp73 in HCC.
Beschreibung:Gesehen am 06.07.2023
Beschreibung:Online Resource
ISSN:1551-4005
DOI:10.4161/cc.9.13.12110

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