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A comparison of dacron versus flocked nylon swabs for anal cytology specimen collection

Objectives: We compared the performance of commonly used Dacron versus flocked nylon swabs for anal cytology. Study Design: From 23 HIV-positive men screened at Kaiser Permanente San Francisco (San Francisco, Calif., USA), 2 anal specimens were collected, 1 with each swab in random order, and placed...

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Main Authors: Gage, Julia C. (Author) , Ghosh, Arpita (Author) , Borgonovo, Sylvia (Author) , Follansbee, Stephen (Author) , Wentzensen, Nicolas (Author) , Gravitt, Patti E. (Author) , Grabe, Niels (Author) , Lahrmann, Bernd (Author) , Castle, Philip E. (Author)
Format: Article (Journal)
Language:English
Published: July 22, 2011
In: Acta cytologica
Year: 2011, Volume: 55, Issue: 4, Pages: 364-367
ISSN:1938-2650
DOI:10.1159/000329488
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000329488
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Author Notes:Julia C. Gage, Arpita Ghosh, Sylvia Borgonovo, Stephen Follansbee, Nicolas Wentzensen, Patti E. Gravitt, Niels Grabe, Bernd Lahrmann, Philip E. Castle
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Summary:Objectives: We compared the performance of commonly used Dacron versus flocked nylon swabs for anal cytology. Study Design: From 23 HIV-positive men screened at Kaiser Permanente San Francisco (San Francisco, Calif., USA), 2 anal specimens were collected, 1 with each swab in random order, and placed into liquid cytology medium. Specimens were tested for cellularity by quantifying a genomic DNA (erv-3). The number of cells was assessed from prepared slides by automated image analysis. Performance was compared between swabs using 2-sample t tests and standard crossover trial analysis methods accounting for period effect. Results: Flocked swabs collected slightly more erv-3 cells than Dacron for the first sample although not significantly (p = 0.18) and a similar number of erv-3 cells for the second sample (p = 0.85). Flocked swabs collected slightly more cells per slide than the Dacron swabs at both time periods although this was only significant in the second time period (p = 0.42 and 0.03 for first and second periods, respectively). In crossover trial analysis, flocked swabs outperformed Dacron for cell count per slide based on slide imaging (p = 0.03), but Dacron and flocked swabs performed similarly based on erv-3 quantification (p = 0.14). Conclusions: Further studies should determine whether flocked swabs increase the representation of diagnostically important cells compared to Dacron.
Item Description:Gesehen am 06.07.2023
Physical Description:Online Resource
ISSN:1938-2650
DOI:10.1159/000329488

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