LXR signaling controls homeostatic dendritic cell maturation
Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the context in which an antigen is perceived, preserving the balance between immunity and tolerance. Whereas the pathways driving immunogenic maturation in response to infectious insults are well-characterized, the sig...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 May 2023
|
| In: |
Science immunology
Year: 2023, Jahrgang: 8, Heft: 83, Pages: 1-18 |
| ISSN: | 2470-9468 |
| DOI: | 10.1126/sciimmunol.add3955 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciimmunol.add3955 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/sciimmunol.add3955 
|
| Verfasserangaben: | Victor Bosteels, Sandra Maréchal, Clint De Nolf, Sofie Rennen, Jonathan Maelfait, Simon J. Tavernier, Jessica Vetters, Evelien Van De Velde, Farzaneh Fayazpour, Kim Deswarte, Alexander Lamoot, Julie Van Duyse, Liesbet Martens, Cédric Bosteels, Ria Roelandt, Annelies Emmaneel, Sofie Van Gassen, Louis Boon, Gert Van Isterdael, Isabelle Guillas, Niels Vandamme, Doris Höglinger, Bruno G. De Geest, Wilfried Le Goff, Yvan Saeys, Kodi S. Ravichandran, Bart N. Lambrecht, Sophie Janssens |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1852086262 | ||
| 003 | DE-627 | ||
| 005 | 20240806135500.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230706s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1126/sciimmunol.add3955 |2 doi | |
| 035 | |a (DE-627)1852086262 | ||
| 035 | |a (DE-599)KXP1852086262 | ||
| 035 | |a (OCoLC)1425214837 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Bosteels, Victor |e VerfasserIn |0 (DE-588)1295119730 |0 (DE-627)1852086637 |4 aut | |
| 245 | 1 | 0 | |a LXR signaling controls homeostatic dendritic cell maturation |c Victor Bosteels, Sandra Maréchal, Clint De Nolf, Sofie Rennen, Jonathan Maelfait, Simon J. Tavernier, Jessica Vetters, Evelien Van De Velde, Farzaneh Fayazpour, Kim Deswarte, Alexander Lamoot, Julie Van Duyse, Liesbet Martens, Cédric Bosteels, Ria Roelandt, Annelies Emmaneel, Sofie Van Gassen, Louis Boon, Gert Van Isterdael, Isabelle Guillas, Niels Vandamme, Doris Höglinger, Bruno G. De Geest, Wilfried Le Goff, Yvan Saeys, Kodi S. Ravichandran, Bart N. Lambrecht, Sophie Janssens |
| 264 | 1 | |c 12 May 2023 | |
| 300 | |a 18 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.07.2023 | ||
| 520 | |a Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the context in which an antigen is perceived, preserving the balance between immunity and tolerance. Whereas the pathways driving immunogenic maturation in response to infectious insults are well-characterized, the signals that drive tolerogenic maturation during homeostasis are still poorly understood. We found that the engulfment of apoptotic cells triggered homeostatic maturation of type 1 conventional DCs (cDC1s) within the spleen. This maturation process could be mimicked by engulfment of empty, nonadjuvanted lipid nanoparticles (LNPs), was marked by intracellular accumulation of cholesterol, and was highly specific to cDC1s. Engulfment of either apoptotic cells or cholesterol-rich LNPs led to the activation of the liver X receptor (LXR) pathway, which promotes the efflux of cellular cholesterol, and repressed genes associated with immunogenic maturation. In contrast, simultaneous engagement of TLR3 to mimic viral infection via administration of poly(I:C)-adjuvanted LNPs repressed the LXR pathway, thus delaying cellular cholesterol efflux and inducing genes that promote T cell-mediated immunity. These data demonstrate that conserved cellular cholesterol efflux pathways are differentially regulated in tolerogenic versus immunogenic cDC1s and suggest that administration of nonadjuvanted cholesterol-rich LNPs may be an approach for inducing tolerogenic DC maturation. | ||
| 700 | 1 | |a Maréchal, Sandra |e VerfasserIn |4 aut | |
| 700 | 1 | |a De Nolf, Clint |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rennen, Sofie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maelfait, Jonathan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tavernier, Simon J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vetters, Jessica |e VerfasserIn |4 aut | |
| 700 | 1 | |a Van De Velde, Evelien |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fayazpour, Farzaneh |e VerfasserIn |4 aut | |
| 700 | 1 | |a Deswarte, Kim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lamoot, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Van Duyse, Julie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martens, Liesbet |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bosteels, Cédric |e VerfasserIn |4 aut | |
| 700 | 1 | |a Roelandt, Ria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Emmaneel, Annelies |e VerfasserIn |4 aut | |
| 700 | 1 | |a Van Gassen, Sofie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Boon, Louis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Van Isterdael, Gert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Guillas, Isabelle |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vandamme, Niels |e VerfasserIn |4 aut | |
| 700 | 1 | |a Höglinger, Doris |e VerfasserIn |0 (DE-588)1079326588 |0 (DE-627)842322345 |0 (DE-576)452371503 |4 aut | |
| 700 | 1 | |a De Geest, Bruno G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Le Goff, Wilfried |e VerfasserIn |4 aut | |
| 700 | 1 | |a Saeys, Yvan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ravichandran, Kodi S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lambrecht, Bart N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Janssens, Sophie |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Science immunology |d Washington, DC : AAAS, 2016 |g 8(2023), 83 vom: Mai, Artikel-ID eadd3955, Seite 1-18 |h Online-Ressource |w (DE-627)863416853 |w (DE-600)2862556-0 |w (DE-576)475004736 |x 2470-9468 |7 nnas |a LXR signaling controls homeostatic dendritic cell maturation |
| 773 | 1 | 8 | |g volume:8 |g year:2023 |g number:83 |g month:05 |g elocationid:eadd3955 |g pages:1-18 |g extent:18 |a LXR signaling controls homeostatic dendritic cell maturation |
| 856 | 4 | 0 | |u https://doi.org/10.1126/sciimmunol.add3955 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.science.org/doi/10.1126/sciimmunol.add3955 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230706 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1079326588 |a Höglinger, Doris |m 1079326588:Höglinger, Doris |d 700000 |d 711000 |e 700000PH1079326588 |e 711000PH1079326588 |k 0/700000/ |k 1/700000/711000/ |p 22 | ||
| 999 | |a KXP-PPN1852086262 |e 4348965986 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"LXR signaling controls homeostatic dendritic cell maturation","title_sort":"LXR signaling controls homeostatic dendritic cell maturation"}],"person":[{"role":"aut","display":"Bosteels, Victor","roleDisplay":"VerfasserIn","given":"Victor","family":"Bosteels"},{"display":"Maréchal, Sandra","roleDisplay":"VerfasserIn","role":"aut","family":"Maréchal","given":"Sandra"},{"family":"De Nolf","given":"Clint","display":"De Nolf, Clint","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Rennen, Sofie","roleDisplay":"VerfasserIn","role":"aut","family":"Rennen","given":"Sofie"},{"role":"aut","display":"Maelfait, Jonathan","roleDisplay":"VerfasserIn","given":"Jonathan","family":"Maelfait"},{"family":"Tavernier","given":"Simon J.","roleDisplay":"VerfasserIn","display":"Tavernier, Simon J.","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Vetters, Jessica","given":"Jessica","family":"Vetters"},{"family":"Van De Velde","given":"Evelien","roleDisplay":"VerfasserIn","display":"Van De Velde, Evelien","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Fayazpour, Farzaneh","given":"Farzaneh","family":"Fayazpour"},{"given":"Kim","family":"Deswarte","role":"aut","display":"Deswarte, Kim","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Lamoot, Alexander","roleDisplay":"VerfasserIn","given":"Alexander","family":"Lamoot"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Van Duyse, Julie","given":"Julie","family":"Van Duyse"},{"family":"Martens","given":"Liesbet","roleDisplay":"VerfasserIn","display":"Martens, Liesbet","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Bosteels, Cédric","role":"aut","family":"Bosteels","given":"Cédric"},{"given":"Ria","family":"Roelandt","role":"aut","roleDisplay":"VerfasserIn","display":"Roelandt, Ria"},{"family":"Emmaneel","given":"Annelies","roleDisplay":"VerfasserIn","display":"Emmaneel, Annelies","role":"aut"},{"given":"Sofie","family":"Van Gassen","role":"aut","roleDisplay":"VerfasserIn","display":"Van Gassen, Sofie"},{"display":"Boon, Louis","roleDisplay":"VerfasserIn","role":"aut","family":"Boon","given":"Louis"},{"family":"Van Isterdael","given":"Gert","display":"Van Isterdael, Gert","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Guillas, Isabelle","role":"aut","family":"Guillas","given":"Isabelle"},{"role":"aut","display":"Vandamme, Niels","roleDisplay":"VerfasserIn","given":"Niels","family":"Vandamme"},{"family":"Höglinger","given":"Doris","display":"Höglinger, Doris","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"De Geest, Bruno G.","roleDisplay":"VerfasserIn","given":"Bruno G.","family":"De Geest"},{"roleDisplay":"VerfasserIn","display":"Le Goff, Wilfried","role":"aut","family":"Le Goff","given":"Wilfried"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Saeys, Yvan","given":"Yvan","family":"Saeys"},{"role":"aut","display":"Ravichandran, Kodi S.","roleDisplay":"VerfasserIn","given":"Kodi S.","family":"Ravichandran"},{"roleDisplay":"VerfasserIn","display":"Lambrecht, Bart N.","role":"aut","family":"Lambrecht","given":"Bart N."},{"role":"aut","display":"Janssens, Sophie","roleDisplay":"VerfasserIn","given":"Sophie","family":"Janssens"}],"recId":"1852086262","language":["eng"],"note":["Gesehen am 06.07.2023"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1126/sciimmunol.add3955"],"eki":["1852086262"]},"origin":[{"dateIssuedDisp":"12 May 2023","dateIssuedKey":"2023"}],"name":{"displayForm":["Victor Bosteels, Sandra Maréchal, Clint De Nolf, Sofie Rennen, Jonathan Maelfait, Simon J. Tavernier, Jessica Vetters, Evelien Van De Velde, Farzaneh Fayazpour, Kim Deswarte, Alexander Lamoot, Julie Van Duyse, Liesbet Martens, Cédric Bosteels, Ria Roelandt, Annelies Emmaneel, Sofie Van Gassen, Louis Boon, Gert Van Isterdael, Isabelle Guillas, Niels Vandamme, Doris Höglinger, Bruno G. De Geest, Wilfried Le Goff, Yvan Saeys, Kodi S. Ravichandran, Bart N. Lambrecht, Sophie Janssens"]},"relHost":[{"origin":[{"publisherPlace":"Washington, DC","dateIssuedDisp":"[2016]-","publisher":"AAAS"}],"id":{"eki":["863416853"],"zdb":["2862556-0"],"issn":["2470-9468"]},"name":{"displayForm":["American Association for the Advancement of Science"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Science immunology","title":"Science immunology"}],"pubHistory":["Volume 1, issue 1 (July 2016)-"],"part":{"extent":"18","volume":"8","text":"8(2023), 83 vom: Mai, Artikel-ID eadd3955, Seite 1-18","issue":"83","pages":"1-18","year":"2023"},"note":["Gesehen am 13. September 2021"],"disp":"LXR signaling controls homeostatic dendritic cell maturationScience immunology","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"863416853","language":["eng"]}],"physDesc":[{"extent":"18 S."}]} | ||
| SRT | |a BOSTEELSVILXRSIGNALI1220 | ||