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Critical vasospasm during fingolimod (fty720) treatment in a patient with multiple sclerosis

We report on a woman who developed critical arterial vasospasm of the left arm within 7 days after having started treatment with Fingolimod (FTY720). Fingolimod is an orally administered modulator of the sphingosine-1-phosphate (S1P) receptor family, acting at 4 of the 5 G protein-coupled S1P recept...

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Bibliographic Details
Main Authors: Schwarz, Alexander (Author) , Korporal-Kuhnke, Mirjam (Author) , Hosch, Waldemar P. (Author) , Max, R. (Author) , Wildemann, Brigitte (Author)
Format: Article (Journal)
Language:English
Published: June 14, 2010
In: Neurology
Year: 2010, Volume: 74, Issue: 24, Pages: 2022-2024
ISSN:1526-632X
DOI:10.1212/WNL.0b013e3181e3972b
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1212/WNL.0b013e3181e3972b
Verlag, lizenzpflichtig, Volltext: https://n.neurology.org/content/74/24/2022
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Author Notes:A. Schwarz, M. Korporal, W. Hosch, R. Max, B. Wildemann

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520 |a We report on a woman who developed critical arterial vasospasm of the left arm within 7 days after having started treatment with Fingolimod (FTY720). Fingolimod is an orally administered modulator of the sphingosine-1-phosphate (S1P) receptor family, acting at 4 of the 5 G protein-coupled S1P receptors. It causes a reversible sequestration of lymphocytes into lymph nodes, thereby inhibiting their migration to sites of inflammation. Fingolimod is currently tested in clinical trials for the treatment of relapsing-remitting multiple sclerosis (RRMS). As S1P receptors regulate numerous cellular processes in different tissues, Fingolimod exhibits the capacity to induce versatile pharmacologic effects. 
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