Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals
The superior colliculus (SC), a conserved midbrain node with extensive long-range connectivity throughout the brain, is a key structure for innate behaviors. Descending cortical pathways are increasingly recognized as central control points for SC-mediated behaviors, but how cortico-collicular pathw...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 19, 2023
|
| In: |
PLoS biology
Year: 2023, Volume: 21, Issue: 5, Pages: 1-29 |
| ISSN: | 1545-7885 |
| DOI: | 10.1371/journal.pbio.3002126 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pbio.3002126 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002126 
|
| Author Notes: | Jesús Martín-Cortecero, Emilio Ulises Isaías-Camacho, Berin Boztepe, Katharina Ziegler, Rebecca Audrey Mease, Alexander Groh |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1852134062 | ||
| 003 | DE-627 | ||
| 005 | 20240307074239.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230707s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pbio.3002126 |2 doi | |
| 035 | |a (DE-627)1852134062 | ||
| 035 | |a (DE-599)KXP1852134062 | ||
| 035 | |a (OCoLC)1425215074 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Martín-Cortecero, Jesús |e VerfasserIn |0 (DE-588)1183428464 |0 (DE-627)1663200025 |4 aut | |
| 245 | 1 | 0 | |a Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals |c Jesús Martín-Cortecero, Emilio Ulises Isaías-Camacho, Berin Boztepe, Katharina Ziegler, Rebecca Audrey Mease, Alexander Groh |
| 264 | 1 | |c May 19, 2023 | |
| 300 | |a 29 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.07.2023 | ||
| 520 | |a The superior colliculus (SC), a conserved midbrain node with extensive long-range connectivity throughout the brain, is a key structure for innate behaviors. Descending cortical pathways are increasingly recognized as central control points for SC-mediated behaviors, but how cortico-collicular pathways coordinate SC activity at the cellular level is poorly understood. Moreover, despite the known role of the SC as a multisensory integrator, the involvement of the SC in the somatosensory system is largely unexplored in comparison to its involvement in the visual and auditory systems. Here, we mapped the connectivity of the whisker-sensitive region of the SC in mice with trans-synaptic and intersectional tracing tools and in vivo electrophysiology. The results reveal a novel trans-collicular connectivity motif in which neurons in motor- and somatosensory cortices impinge onto the brainstem-SC-brainstem sensory-motor arc and onto SC-midbrain output pathways via only one synapse in the SC. Intersectional approaches and optogenetically assisted connectivity quantifications in vivo reveal convergence of motor and somatosensory cortical input on individual SC neurons, providing a new framework for sensory-motor integration in the SC. More than a third of the cortical recipient neurons in the whisker SC are GABAergic neurons, which include a hitherto unknown population of GABAergic projection neurons targeting thalamic nuclei and the zona incerta. These results pinpoint a whisker region in the SC of mice as a node for the integration of somatosensory and motor cortical signals via parallel excitatory and inhibitory trans-collicular pathways, which link cortical and subcortical whisker circuits for somato-motor integration. | ||
| 650 | 4 | |a Axons | |
| 650 | 4 | |a Brainstem | |
| 650 | 4 | |a Cerebellar nuclei | |
| 650 | 4 | |a Fluorescence imaging | |
| 650 | 4 | |a Motor neurons | |
| 650 | 4 | |a Neurons | |
| 650 | 4 | |a Sensory perception | |
| 650 | 4 | |a Vibrissae | |
| 700 | 1 | |a Isaías-Camacho, Emilio Ulises |d 1990- |e VerfasserIn |0 (DE-588)1283251027 |0 (DE-627)1839054549 |4 aut | |
| 700 | 1 | |a Boztepe, Berin |d 1996- |e VerfasserIn |0 (DE-588)1283251558 |0 (DE-627)1839055898 |4 aut | |
| 700 | 1 | |a Ziegler, Katharina |d 1992- |e VerfasserIn |0 (DE-588)1283252309 |0 (DE-627)1839057203 |4 aut | |
| 700 | 1 | |a Mease, Rebecca A. |d 1980- |e VerfasserIn |0 (DE-588)1167342461 |0 (DE-627)1031604588 |0 (DE-576)511106653 |4 aut | |
| 700 | 1 | |a Groh, Alexander |e VerfasserIn |0 (DE-588)138976325 |0 (DE-627)70316984X |0 (DE-576)309274117 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a Public Library of Science |t PLoS biology |d Lawrence, KS : PLoS, 2003 |g 21(2023), 5 vom: Mai, Artikel-ID e3002126, Seite 1-29 |h Online-Ressource |w (DE-627)373755597 |w (DE-600)2126773-X |w (DE-576)109104846 |x 1545-7885 |7 nnas |
| 773 | 1 | 8 | |g volume:21 |g year:2023 |g number:5 |g month:05 |g elocationid:e3002126 |g pages:1-29 |g extent:29 |a Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.pbio.3002126 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002126 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230707 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 138976325 |a Groh, Alexander |m 138976325:Groh, Alexander |d 50000 |d 53200 |e 50000PG138976325 |e 53200PG138976325 |k 0/50000/ |k 1/50000/53200/ |p 6 |y j | ||
| 998 | |g 1167342461 |a Mease, Rebecca A. |m 1167342461:Mease, Rebecca A. |d 910000 |d 950000 |d 950950 |e 910000PM1167342461 |e 950000PM1167342461 |e 950950PM1167342461 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 5 | ||
| 998 | |g 1283252309 |a Ziegler, Katharina |m 1283252309:Ziegler, Katharina |d 50000 |d 53200 |e 50000PZ1283252309 |e 53200PZ1283252309 |k 0/50000/ |k 1/50000/53200/ |p 4 | ||
| 998 | |g 1283251558 |a Boztepe, Berin |m 1283251558:Boztepe, Berin |d 910000 |d 911100 |e 910000PB1283251558 |e 911100PB1283251558 |k 0/910000/ |k 1/910000/911100/ |p 3 | ||
| 998 | |g 1283251027 |a Isaías-Camacho, Emilio Ulises |m 1283251027:Isaías-Camacho, Emilio Ulises |d 50000 |d 53200 |e 50000PI1283251027 |e 53200PI1283251027 |k 0/50000/ |k 1/50000/53200/ |p 2 | ||
| 998 | |g 1183428464 |a Martín-Cortecero, Jesús |m 1183428464:Martín-Cortecero, Jesús |d 50000 |d 53200 |e 50000PM1183428464 |e 53200PM1183428464 |k 0/50000/ |k 1/50000/53200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1852134062 |e 4349571434 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","given":"Jesús","display":"Martín-Cortecero, Jesús","family":"Martín-Cortecero"},{"display":"Isaías-Camacho, Emilio Ulises","given":"Emilio Ulises","role":"aut","family":"Isaías-Camacho"},{"role":"aut","given":"Berin","display":"Boztepe, Berin","family":"Boztepe"},{"family":"Ziegler","role":"aut","display":"Ziegler, Katharina","given":"Katharina"},{"family":"Mease","role":"aut","display":"Mease, Rebecca A.","given":"Rebecca A."},{"given":"Alexander","display":"Groh, Alexander","role":"aut","family":"Groh"}],"id":{"doi":["10.1371/journal.pbio.3002126"],"eki":["1852134062"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Jesús Martín-Cortecero, Emilio Ulises Isaías-Camacho, Berin Boztepe, Katharina Ziegler, Rebecca Audrey Mease, Alexander Groh"]},"relHost":[{"part":{"issue":"5","volume":"21","year":"2023","pages":"1-29","extent":"29","text":"21(2023), 5 vom: Mai, Artikel-ID e3002126, Seite 1-29"},"name":{"displayForm":["Public Library of Science"]},"origin":[{"dateIssuedDisp":"2003-","publisher":"PLoS","publisherPlace":"Lawrence, KS","dateIssuedKey":"2003"}],"note":["Gesehen am 25.08.20"],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Public Library of SciencePLoS biology","pubHistory":["1.2003 -"],"id":{"zdb":["2126773-X"],"issn":["1545-7885"],"eki":["373755597"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"PLoS biology","title_sort":"PLoS biology"}],"titleAlt":[{"title":"Biology"}],"corporate":[{"display":"Public Library of Science","role":"aut"}],"recId":"373755597","language":["eng"]}],"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"May 19, 2023"}],"note":["Gesehen am 07.07.2023"],"title":[{"title":"Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals","title_sort":"Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals"}],"language":["eng"],"physDesc":[{"extent":"29 S."}],"recId":"1852134062"} | ||
| SRT | |a MARTINCORTMONOSYNAPT1920 | ||