Nutritional calcium supply dependent calcium balance, bone calcification and calcium isotope ratios in rats
Serum calcium isotopes (δ44/42Ca) have been suggested as a non-invasive and sensitive Ca balance marker. Quantitative δ44/42Ca changes associated with Ca flux across body compartment barriers relative to the dietary Ca and the correlation of δ44/42CaSerum with bone histology are unknown. We analyzed...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 July 2022
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| In: |
International journal of molecular sciences
Year: 2022, Jahrgang: 23, Heft: 14, Pages: 1-20 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms23147796 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms23147796 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/23/14/7796 
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| Verfasserangaben: | Jeremy Rott, Eva Teresa Toepfer, Maria Bartosova, Ana Kolevica, Alexander Heuser, Michael Rabe, Geert Behets, Patrick C. D’Haese, Viktoria Eichwald, Manfred Jugold, Ivan Damgov, Sotirios G. Zarogiannis, Rukshana Shroff, Anton Eisenhauer and Claus Peter Schmitt |
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| 245 | 1 | 0 | |a Nutritional calcium supply dependent calcium balance, bone calcification and calcium isotope ratios in rats |c Jeremy Rott, Eva Teresa Toepfer, Maria Bartosova, Ana Kolevica, Alexander Heuser, Michael Rabe, Geert Behets, Patrick C. D’Haese, Viktoria Eichwald, Manfred Jugold, Ivan Damgov, Sotirios G. Zarogiannis, Rukshana Shroff, Anton Eisenhauer and Claus Peter Schmitt |
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| 520 | |a Serum calcium isotopes (δ44/42Ca) have been suggested as a non-invasive and sensitive Ca balance marker. Quantitative δ44/42Ca changes associated with Ca flux across body compartment barriers relative to the dietary Ca and the correlation of δ44/42CaSerum with bone histology are unknown. We analyzed Ca and δ44/42Ca by mass-spectrometry in rats after two weeks of standard-Ca-diet (0.5%) and after four subsequent weeks of standard- and of low-Ca-diet (0.25%). In animals on a low-Ca-diet net Ca gain was 61 ± 3% and femur Ca content 68 ± 41% of standard-Ca-diet, bone mineralized area per section area was 68 ± 15% compared to standard-Ca-diet. δ44/42Ca was similar in the diets, and decreased in feces and urine and increased in serum in animals on low-Ca-diet. δ44/42CaBone was higher in animals on low-Ca-diet, lower in the diaphysis than the metaphysis and epiphysis, and unaffected by gender. Independent of diet, δ44/42CaBone was similar in the femora and ribs. At the time of sacrifice, δ44/42CaSerum inversely correlated with intestinal Ca uptake and histological bone mineralization markers, but not with Ca content and bone mineral density by µCT. In conclusion, δ44/42CaBone was bone site specific, but mechanical stress and gender independent. Low-Ca-diet induced marked changes in feces, serum and urine δ44/42Ca in growing rats. δ44/42CaSerum inversely correlated with markers of bone mineralization. | ||
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