Post-COVID-19 syndrome and diabetes mellitus: a propensity-matched analysis of the International HOPE-II COVID-19 registry
BackgroundDiabetes mellitus (DM) is one of the most frequent comorbidities in patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with a higher rate of severe course of coronavirus disease (COVID-19). However, data about post-COVID-19 syndrome (PCS) in patients with...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
16 May 2023
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| In: |
Frontiers in endocrinology
Year: 2023, Volume: 14, Pages: 1-12 |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2023.1167087 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fendo.2023.1167087 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fendo.2023.1167087 
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| Author Notes: | Mohammad Abumayyaleh, Iván J. Núñez Gil, María C. Viana-LLamas, Sergio Raposeiras Roubin, Rodolfo Romero, Emilio Alfonso-Rodríguez, Aitor Uribarri, Gisela Feltes, Víctor Manuel Becerra-Muñoz, Francesco Santoro, Martino Pepe, Alex Fernando Castro Mejía, Jaime Signes-Costa, Adelina Gonzalez, Francisco Marín, Javier López-País, Edoardo Manzone, Olalla Vazquez Cancela, Carolina Espejo Paeres, Alvaro López Masjuan, Lazar Velicki, Christel Weiß, David Chipayo, Antonio Fernandez-Ortiz, Ibrahim El-Battrawy, Ibrahim Akin and HOPE COVID-19 investigators |
| Summary: | BackgroundDiabetes mellitus (DM) is one of the most frequent comorbidities in patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with a higher rate of severe course of coronavirus disease (COVID-19). However, data about post-COVID-19 syndrome (PCS) in patients with DM are limited.MethodsThis multicenter, propensity score-matched study compared long-term follow-up data about cardiovascular, neuropsychiatric, respiratory, gastrointestinal, and other symptoms in 8,719 patients with DM to those without DM. The 1:1 propensity score matching (PSM) according to age and sex resulted in 1,548 matched pairs.ResultsDiabetics and nondiabetics had a mean age of 72.6 ± 12.7 years old. At follow-up, cardiovascular symptoms such as dyspnea and increased resting heart rate occurred less in patients with DM (13.2% vs. 16.4%; p = 0.01) than those without DM (2.8% vs. 5.6%; p = 0.05), respectively. The incidence of newly diagnosed arterial hypertension was slightly lower in DM patients as compared to non-DM patients (0.5% vs. 1.6%; p = 0.18). Abnormal spirometry was observed more in patients with DM than those without DM (18.8% vs. 13; p = 0.24). Paranoia was diagnosed more frequently in patients with DM than in non-DM patients at follow-up time (4% vs. 1.2%; p = 0.009). The incidence of newly diagnosed renal insufficiency was higher in patients suffering from DM as compared to patients without DM (4.8% vs. 2.6%; p = 0.09). The rate of readmission was comparable in patients with and without DM (19.7% vs. 18.3%; p = 0.61). The reinfection rate with COVID-19 was comparable in both groups (2.9% in diabetics vs. 2.3% in nondiabetics; p = 0.55). Long-term mortality was higher in DM patients than in non-DM patients (33.9% vs. 29.1%; p = 0.005).ConclusionsThe mortality rate was higher in patients with DM type II as compared to those without DM. Readmission and reinfection rates with COVID-19 were comparable in both groups. The incidence of cardiovascular symptoms was higher in patients without DM. |
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| Item Description: | Gesehen am 10.07.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2023.1167087 |