Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo
The intercalated disc (ID) is a highly specialized cell-cell contact structure that ensures mechanical and electric coupling of contracting cardiomyocytes. Recently, the ID has been recognized to be a hot spot of cardiac disease, in particular inherited cardiomyopathy. Given its complex structure an...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 Jan 2010
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| In: |
Circulation research
Year: 2010, Jahrgang: 106, Heft: 5, Pages: 880-890 |
| ISSN: | 1524-4571 |
| DOI: | 10.1161/CIRCRESAHA.109.213256 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1161/CIRCRESAHA.109.213256 Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.109.213256 
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| Verfasserangaben: | Thalia S. Seeger, Derk Frank, Claudia Rohr, Rainer Will, Steffen Just, Christine Grund, Robert Lyon, Mark Luedde, Manfred Koegl, Farah Sheikh, Wolfgang Rottbauer, Werner W. Franke, Hugo A. Katus, Eric N. Olson, Norbert Frey |
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| 520 | |a The intercalated disc (ID) is a highly specialized cell-cell contact structure that ensures mechanical and electric coupling of contracting cardiomyocytes. Recently, the ID has been recognized to be a hot spot of cardiac disease, in particular inherited cardiomyopathy. Given its complex structure and function we hypothesized that important molecular constituents of the ID still remain unknown. | ||
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