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Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk

The WNT/β-catenin signaling pathway upregulates transcription of genes involved in cell proliferation and cancer progression; it has been implicated in colorectal adenoma formation. To date, no studies have examined polymorphisms in WNT genes or WNT gene-environment interactions in relation to adeno...

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Main Authors: Galbraith, Rachel L. (Author) , Poole, Elizabeth M. (Author) , Duggan, David (Author) , Muehling, Jill (Author) , Hsu, Li (Author) , Makar, Karen (Author) , Xiao, Liren (Author) , Potter, John D. (Author) , Ulrich, Cornelia (Author)
Format: Article (Journal)
Language:English
Published: 05 May 2011
In: Nutrition and cancer
Year: 2011, Volume: 63, Issue: 4, Pages: 558-564
ISSN:1532-7914
DOI:10.1080/01635581.2011.542539
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/01635581.2011.542539
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Author Notes:Rachel L. Galbraith, Elizabeth M. Poole, David Duggan, Jill Muehling, Li Hsu, Karen Makar, Liren Xiao, John D. Potter, and Cornelia M. Ulrich
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Summary:The WNT/β-catenin signaling pathway upregulates transcription of genes involved in cell proliferation and cancer progression; it has been implicated in colorectal adenoma formation. To date, no studies have examined polymorphisms in WNT genes or WNT gene-environment interactions in relation to adenoma risk. Within a colonoscopy-based case-control study of 628 adenoma cases and 516 polyp-free controls, we analyzed two tagSNPs in WNT6 (rs6747776 G > C, rs6754599 G > C) and WNT10A (rs7349332 G > A, rs10177996 A > G). The WNT6 rs6747776 homozygous minor allele (CC) was associated with increased risk of colorectal adenoma (OR = 2.75, 95% CI: 1.03-7.31). We observed a statistically significant interaction between WNT6 rs6747776 and the proportion of calories from total fat (P-int = 0.02), where the highest risk was observed among those with minor alleles and lowest fat intake. We also detected a marginally significant (0.05 < P ≤ 0.10) interaction with fish intake (P-int = 0.09). Additionally, a marginally significant interaction was observed between proportion of calories from saturated fat and the WNT10A rs7349332 polymorphism. Our results suggest that genetic variability in the WNT pathway may play a role in colorectal adenoma formation or may partly mediate the increased risk of colorectal cancer associated with fat intake.
Item Description:Gesehen am 13.07.2023
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Angabe zum PDF: Autorenmanuskript: verfügbar in PMC 2015 Mai 13, 13 Seiten
Physical Description:Online Resource
ISSN:1532-7914
DOI:10.1080/01635581.2011.542539

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