Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk
The WNT/β-catenin signaling pathway upregulates transcription of genes involved in cell proliferation and cancer progression; it has been implicated in colorectal adenoma formation. To date, no studies have examined polymorphisms in WNT genes or WNT gene-environment interactions in relation to adeno...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
05 May 2011
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| In: |
Nutrition and cancer
Year: 2011, Volume: 63, Issue: 4, Pages: 558-564 |
| ISSN: | 1532-7914 |
| DOI: | 10.1080/01635581.2011.542539 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/01635581.2011.542539
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| Author Notes: | Rachel L. Galbraith, Elizabeth M. Poole, David Duggan, Jill Muehling, Li Hsu, Karen Makar, Liren Xiao, John D. Potter, and Cornelia M. Ulrich |
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| 520 | |a The WNT/β-catenin signaling pathway upregulates transcription of genes involved in cell proliferation and cancer progression; it has been implicated in colorectal adenoma formation. To date, no studies have examined polymorphisms in WNT genes or WNT gene-environment interactions in relation to adenoma risk. Within a colonoscopy-based case-control study of 628 adenoma cases and 516 polyp-free controls, we analyzed two tagSNPs in WNT6 (rs6747776 G > C, rs6754599 G > C) and WNT10A (rs7349332 G > A, rs10177996 A > G). The WNT6 rs6747776 homozygous minor allele (CC) was associated with increased risk of colorectal adenoma (OR = 2.75, 95% CI: 1.03-7.31). We observed a statistically significant interaction between WNT6 rs6747776 and the proportion of calories from total fat (P-int = 0.02), where the highest risk was observed among those with minor alleles and lowest fat intake. We also detected a marginally significant (0.05 < P ≤ 0.10) interaction with fish intake (P-int = 0.09). Additionally, a marginally significant interaction was observed between proportion of calories from saturated fat and the WNT10A rs7349332 polymorphism. Our results suggest that genetic variability in the WNT pathway may play a role in colorectal adenoma formation or may partly mediate the increased risk of colorectal cancer associated with fat intake. | ||
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