Associations of SLC6A4 methylation with salivary cortisol, salivary alpha-amylase, and subjective stress in everyday life
Dysregulations of the hypothalamic-pituitary-adrenal (HPA) and sympatho-adrenal medullary (SAM) axis are associated with mental and somatic illness. However, there is lack of knowledge regarding the molecular mechanisms underlying these effects. Epigenetic states in the serotonin transporter gene (S...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2023
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| In: |
Psychoneuroendocrinology
Year: 2023, Jahrgang: 153, Pages: 1-9 |
| ISSN: | 1873-3360 |
| DOI: | 10.1016/j.psyneuen.2023.106283 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.psyneuen.2023.106283 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0306453023002615 
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| Verfasserangaben: | Martin Stoffel, Stefanie Rahn, Andreas B. Neubauer, Markus Moessner, Corina Aguilar-Raab, Beate Ditzen |
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| 520 | |a Dysregulations of the hypothalamic-pituitary-adrenal (HPA) and sympatho-adrenal medullary (SAM) axis are associated with mental and somatic illness. However, there is lack of knowledge regarding the molecular mechanisms underlying these effects. Epigenetic states in the serotonin transporter gene (SLC6A4) were shown to be associated with stress in various forms. We hypothesized that levels of DNA methylation (DNAm) of SLC6A4 would be associated with altered SAM- and HPA regulation in daily life. N = 74 healthy persons participated in the study. ... | ||
| 650 | 4 | |a DNA Methylation | |
| 650 | 4 | |a Ecological Momentary Assessment | |
| 650 | 4 | |a Epigenetics | |
| 650 | 4 | |a Serotonin transporter gene | |
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| 650 | 4 | |a Stress axes | |
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