ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion
Vitamin E (α-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. α-Tocopherol transfer protein (α-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma α-tocopherol level by mediating the secr...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 2010
|
| In: |
The journal of nutritional biochemistry
Year: 2010, Volume: 21, Issue: 5, Pages: 451-456 |
| ISSN: | 1873-4847 |
| DOI: | 10.1016/j.jnutbio.2009.02.002 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jnutbio.2009.02.002 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0955286309000382 
|
| Author Notes: | Mototada Shichiri, Yasukazu Takanezawa, Daisy E. Rotzoll, Yasukazu Yoshida, Tomokuni Kokubu, Kazumitsu Ueda, Hiroshi Tamai, Hiroyuki Arai |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1852822767 | ||
| 003 | DE-627 | ||
| 005 | 20240311131023.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230717s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jnutbio.2009.02.002 |2 doi | |
| 035 | |a (DE-627)1852822767 | ||
| 035 | |a (DE-599)KXP1852822767 | ||
| 035 | |a (OCoLC)1425876859 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Shichiri, Mototada |e VerfasserIn |0 (DE-588)1163847534 |0 (DE-627)1028184298 |0 (DE-576)508249368 |4 aut | |
| 245 | 1 | 0 | |a ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion |c Mototada Shichiri, Yasukazu Takanezawa, Daisy E. Rotzoll, Yasukazu Yoshida, Tomokuni Kokubu, Kazumitsu Ueda, Hiroshi Tamai, Hiroyuki Arai |
| 264 | 1 | |c May 2010 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.07.2023 | ||
| 520 | |a Vitamin E (α-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. α-Tocopherol transfer protein (α-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma α-tocopherol level by mediating the secretion of α-tocopherol by the liver. However, the mechanisms underlying hepatic α-tocopherol secretion are not fully understood. This study was undertaken to elucidate the mechanism of α-tocopherol re-efflux from hepatocytes, the cells that have the most important role in regulating plasma-α-tocopherol concentrations. From in vitro experiments using [3H]α-tocopheryl acetate and McARH7777 cells that stably express α-tocopherol transfer protein (α-TTP), the following results were obtained. First, addition of apolipoprotein A-I (apoA-I), a direct acceptor of the ATP-binding cassette transporter A1 (ABCA1)-secreted lipids, increased α-tocopherol secretion in a dose-dependent manner. Second, probucol, an antiatherogenic compound reported to be an inactivator of ABCA1 reduced hepatic α-tocopherol secretion. Third, ABCA1-RNAi suppressed hepatic α-tocopherol secretion. In a mouse in vivo experiment, addition of 1% probucol to the diet decreased plasma α-tocopherol concentrations. These results strongly suggest that ABCA1 is substantially involved in hepatic α-tocopherol secretion. | ||
| 650 | 4 | |a Apolipoprotein A-I (apoA-I) | |
| 650 | 4 | |a ATP-Binding cassette transporter A1 (ABCA1) | |
| 650 | 4 | |a Hepatocyte | |
| 650 | 4 | |a Probucol | |
| 650 | 4 | |a α-Tocopherol | |
| 650 | 4 | |a α-Tocopherol transfer protein (α-TTP) | |
| 700 | 1 | |a Takanezawa, Yasukazu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rotzoll, Daisy E. |e VerfasserIn |0 (DE-588)107649837X |0 (DE-627)834993511 |0 (DE-576)171491408 |4 aut | |
| 700 | 1 | |a Yoshida, Yasukazu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kokubu, Tomokuni |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ueda, Kazumitsu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tamai, Hiroshi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Arai, Hiroyuki |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of nutritional biochemistry |d New York, NY [u.a.] : Elsevier, 1990 |g 21(2010), 5, Seite 451-456 |h Online-Ressource |w (DE-627)30059593X |w (DE-600)1483155-7 |w (DE-576)259483869 |x 1873-4847 |7 nnas |a ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion |
| 773 | 1 | 8 | |g volume:21 |g year:2010 |g number:5 |g pages:451-456 |g extent:6 |a ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jnutbio.2009.02.002 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0955286309000382 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230717 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 107649837X |a Rotzoll, Daisy E. |m 107649837X:Rotzoll, Daisy E. |d 910000 |d 910500 |e 910000PR107649837X |e 910500PR107649837X |k 0/910000/ |k 1/910000/910500/ |p 3 | ||
| 999 | |a KXP-PPN1852822767 |e 4354330091 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Mototada Shichiri, Yasukazu Takanezawa, Daisy E. Rotzoll, Yasukazu Yoshida, Tomokuni Kokubu, Kazumitsu Ueda, Hiroshi Tamai, Hiroyuki Arai"]},"id":{"eki":["1852822767"],"doi":["10.1016/j.jnutbio.2009.02.002"]},"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"May 2010"}],"relHost":[{"title":[{"title_sort":"journal of nutritional biochemistry","title":"The journal of nutritional biochemistry"}],"recId":"30059593X","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretionThe journal of nutritional biochemistry","note":["Gesehen am 22.07.11"],"part":{"extent":"6","volume":"21","text":"21(2010), 5, Seite 451-456","issue":"5","pages":"451-456","year":"2010"},"pubHistory":["1.1990 -"],"id":{"issn":["1873-4847"],"zdb":["1483155-7"],"eki":["30059593X"]},"origin":[{"dateIssuedKey":"1990","publisher":"Elsevier","dateIssuedDisp":"1990-","publisherPlace":"New York, NY [u.a.]"}],"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"6 S."}],"person":[{"family":"Shichiri","given":"Mototada","display":"Shichiri, Mototada","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Yasukazu","family":"Takanezawa","role":"aut","roleDisplay":"VerfasserIn","display":"Takanezawa, Yasukazu"},{"role":"aut","display":"Rotzoll, Daisy E.","roleDisplay":"VerfasserIn","given":"Daisy E.","family":"Rotzoll"},{"given":"Yasukazu","family":"Yoshida","role":"aut","roleDisplay":"VerfasserIn","display":"Yoshida, Yasukazu"},{"role":"aut","display":"Kokubu, Tomokuni","roleDisplay":"VerfasserIn","given":"Tomokuni","family":"Kokubu"},{"given":"Kazumitsu","family":"Ueda","role":"aut","display":"Ueda, Kazumitsu","roleDisplay":"VerfasserIn"},{"given":"Hiroshi","family":"Tamai","role":"aut","roleDisplay":"VerfasserIn","display":"Tamai, Hiroshi"},{"display":"Arai, Hiroyuki","roleDisplay":"VerfasserIn","role":"aut","family":"Arai","given":"Hiroyuki"}],"title":[{"title":"ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion","title_sort":"ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion"}],"language":["eng"],"recId":"1852822767","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 17.07.2023"]} | ||
| SRT | |a SHICHIRIMOATPBINDING2010 | ||