Myeloid derived suppressor cells and their role in tolerance induction in cancer

Myeloid derived suppressor cells (MDSCs) comprise a phenotypically heterogeneous population of cells, which can be found in tumor-bearing mice and in patients with cancer. MDSCs play a central role in the induction of peripheral tolerance. Together with regulatory T cells (Tregs) they promote an imm...

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Hauptverfasser: Fujimura, Taku (VerfasserIn) , Mahnke, Karsten (VerfasserIn) , Enk, Alexander (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 May 2010
In: Journal of dermatological science
Year: 2010, Jahrgang: 59, Heft: 1, Pages: 1-6
ISSN:1873-569X
DOI:10.1016/j.jdermsci.2010.05.001
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jdermsci.2010.05.001
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0923181110001623
Volltext
Verfasserangaben:Taku Fujimura, Karsten Mahnke, Alexander H. Enk

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520 |a Myeloid derived suppressor cells (MDSCs) comprise a phenotypically heterogeneous population of cells, which can be found in tumor-bearing mice and in patients with cancer. MDSCs play a central role in the induction of peripheral tolerance. Together with regulatory T cells (Tregs) they promote an immunosuppressive environment in tumor-bearing hosts. The phenotype of MDSCs differs in humans and mice, and the exact mechanisms of their suppressive function are still controversially discussed. In summary, MDSCs are a group of phenotypically heterogeneous cells of myeloid origin that have common biological activities. In this review, we discuss the definition of MDSCs, the proposed mechanisms of expansion and the recruitment and activation of MDSCs, as well as their biological activities in tumor-bearing hosts to assess the potential therapeutic applications. 
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