Tolerance to 2,4-dinitrofluorobenzene-induced contact hypersensitivity is mediated by CD73-expressing tissue-homing regulatory T cells
Regulatory T cells (Tregs) express CD73, an ectonucleotidase that converts adenosine (Ado) monophosphate to Ado, which has been shown to suppress immune reactions. To investigate the role(s) of CD73+ Tregs during the induction of tolerance, we used a 2,4-dinitrofluorobenzene‒driven contact hypersens...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2023
|
| In: |
The journal of investigative dermatology
Year: 2023, Jahrgang: 143, Heft: 6, Pages: 1011-1022.e8 |
| ISSN: | 1523-1747 |
| DOI: | 10.1016/j.jid.2022.12.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jid.2022.12.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022202X22028871 
|
| Verfasserangaben: | Meihong Da, Luxia Chen, Alexander Enk and Karsten Mahnke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1853191574 | ||
| 003 | DE-627 | ||
| 005 | 20240328081126.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230720s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jid.2022.12.003 |2 doi | |
| 035 | |a (DE-627)1853191574 | ||
| 035 | |a (DE-599)KXP1853191574 | ||
| 035 | |a (OCoLC)1425214897 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Da, Meihong |d 1992- |e VerfasserIn |0 (DE-588)1249237521 |0 (DE-627)1785811959 |4 aut | |
| 245 | 1 | 0 | |a Tolerance to 2,4-dinitrofluorobenzene-induced contact hypersensitivity is mediated by CD73-expressing tissue-homing regulatory T cells |c Meihong Da, Luxia Chen, Alexander Enk and Karsten Mahnke |
| 264 | 1 | |c June 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 20 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar 17. Dezember 2022, Artikelversion 19 May 2023 | ||
| 500 | |a Gesehen am 20.07.2023 | ||
| 520 | |a Regulatory T cells (Tregs) express CD73, an ectonucleotidase that converts adenosine (Ado) monophosphate to Ado, which has been shown to suppress immune reactions. To investigate the role(s) of CD73+ Tregs during the induction of tolerance, we used a 2,4-dinitrofluorobenzene‒driven contact hypersensitivity model, in which tolerance can be induced by pretreating wild type mice with 2,4-dinitrothiocyanobenzene. CD73-deficient mice were unable to acquire tolerance. Likewise, transfer of CD73‒/‒ Tregs failed to suppress 2,4-dinitrofluorobenzene‒induced ear swelling in wild type mice, whereas transfer of wild type‒derived Tregs into CD73‒/‒ mice re-established tolerance. This indicates a crucial role of CD73+ Tregs for skin-induced tolerance. Furthermore, we found that 2,4-dinitrothiocyanobenzene induces more activated CD73+ tissue-homing Tregs (marked by Ki-67, CTLA4, CCR4, CD103, CCR6, and CD49b expression) in draining lymph nodes and blood, eventually accumulating in the skin. The application of anti-CD73 antibodies that block CD73-derived Ado production as well as the injection of Ado deaminase, which degrades Ado in tissues, abrogated tolerance induction. Thus, our data indicate that CD73+ Ado-producing Tregs are crucial for the regulation of contact hypersensitivity reactions and tolerance induction in the skin and that manipulating the function(s) of CD73 in tissues may offer a tool to influence autoimmunity and inflammation in vivo. | ||
| 700 | 1 | |a Chen, Luxia |d 1994- |e VerfasserIn |0 (DE-588)1263590551 |0 (DE-627)1811680607 |4 aut | |
| 700 | 1 | |a Enk, Alexander |d 1963- |e VerfasserIn |0 (DE-588)1032757140 |0 (DE-627)739272535 |0 (DE-576)166173517 |4 aut | |
| 700 | 1 | |a Mahnke, Karsten |e VerfasserIn |0 (DE-588)1022899147 |0 (DE-627)717328007 |0 (DE-576)366144383 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of investigative dermatology |d Amsterdam : Elsevier, 1938 |g 143(2023), 6 vom: Juni, Seite 1011-1022.e8 |h Online-Ressource |w (DE-627)320457990 |w (DE-600)2006902-9 |w (DE-576)09114289X |x 1523-1747 |7 nnas |a Tolerance to 2,4-dinitrofluorobenzene-induced contact hypersensitivity is mediated by CD73-expressing tissue-homing regulatory T cells |
| 773 | 1 | 8 | |g volume:143 |g year:2023 |g number:6 |g month:06 |g pages:1011-1022.e8 |g extent:20 |a Tolerance to 2,4-dinitrofluorobenzene-induced contact hypersensitivity is mediated by CD73-expressing tissue-homing regulatory T cells |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jid.2022.12.003 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0022202X22028871 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230720 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1022899147 |a Mahnke, Karsten |m 1022899147:Mahnke, Karsten |d 910000 |d 911300 |d 50000 |e 910000PM1022899147 |e 911300PM1022899147 |e 50000PM1022899147 |k 0/910000/ |k 1/910000/911300/ |k 0/50000/ |p 4 |y j | ||
| 998 | |g 1032757140 |a Enk, Alexander |m 1032757140:Enk, Alexander |d 910000 |d 911300 |e 910000PE1032757140 |e 911300PE1032757140 |k 0/910000/ |k 1/910000/911300/ |p 3 | ||
| 998 | |g 1263590551 |a Chen, Luxia |m 1263590551:Chen, Luxia |d 50000 |e 50000PC1263590551 |k 0/50000/ |p 2 | ||
| 998 | |g 1249237521 |a Da, Meihong |m 1249237521:Da, Meihong |d 50000 |e 50000PD1249237521 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1853191574 |e 4355601323 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1853191574","note":["Online verfügbar 17. Dezember 2022, Artikelversion 19 May 2023","Gesehen am 20.07.2023"],"name":{"displayForm":["Meihong Da, Luxia Chen, Alexander Enk and Karsten Mahnke"]},"origin":[{"dateIssuedDisp":"June 2023","dateIssuedKey":"2023"}],"id":{"eki":["1853191574"],"doi":["10.1016/j.jid.2022.12.003"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"relHost":[{"origin":[{"dateIssuedDisp":"1938-","publisherPlace":"Amsterdam ; Oxford [u.a.] ; [Erscheinungsort nicht ermittelbar] ; Basingstoke [u.a.]","dateIssuedKey":"1938","publisher":"Elsevier ; Blackwell ; Wiley-Blackwell ; Nature Publishing Group"}],"part":{"issue":"6","extent":"20","year":"2023","text":"143(2023), 6 vom: Juni, Seite 1011-1022.e8","pages":"1011-1022.e8","volume":"143"},"titleAlt":[{"title":"an international journal for research in cutaneous biology"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"The journal of investigative dermatology","title_sort":"journal of investigative dermatology"}],"disp":"Tolerance to 2,4-dinitrofluorobenzene-induced contact hypersensitivity is mediated by CD73-expressing tissue-homing regulatory T cellsThe journal of investigative dermatology","note":["Gesehen am 16.02.16"],"pubHistory":["1.1938 -"],"recId":"320457990","name":{"displayForm":["Society for Investigative Dermatology ; European Society for Dermatological Research"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"id":{"eki":["320457990"],"zdb":["2006902-9"],"issn":["1523-1747"]},"corporate":[{"role":"isb","display":"Society for Investigative Dermatology"}]}],"physDesc":[{"noteIll":"Illustrationen","extent":"20 S."}],"person":[{"family":"Da","display":"Da, Meihong","given":"Meihong","role":"aut"},{"role":"aut","given":"Luxia","family":"Chen","display":"Chen, Luxia"},{"role":"aut","family":"Enk","display":"Enk, Alexander","given":"Alexander"},{"role":"aut","display":"Mahnke, Karsten","family":"Mahnke","given":"Karsten"}],"title":[{"title_sort":"Tolerance to 2,4-dinitrofluorobenzene-induced contact hypersensitivity is mediated by CD73-expressing tissue-homing regulatory T cells","title":"Tolerance to 2,4-dinitrofluorobenzene-induced contact hypersensitivity is mediated by CD73-expressing tissue-homing regulatory T cells"}]} | ||
| SRT | |a DAMEIHONGCTOLERANCET2023 | ||