Buchumschlag

Establishment of a machine learning model for the risk assessment of perineural invasion in head and neck squamous cell carcinoma

Perineural invasion is a prevalent pathological finding in head and neck squamous cell carcinoma and a risk factor for unfavorable survival. An adequate diagnosis of perineural invasion by pathologic examination is limited due to the availability of tumor samples from surgical resection, which can a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Weusthof, Christopher (VerfasserIn) , Burkart, Sebastian (VerfasserIn) , Semmelmayer, Karl (VerfasserIn) , Stögbauer, Fabian (VerfasserIn) , Feng, Bohai (VerfasserIn) , Khorani, Karam (VerfasserIn) , Bode, Sebastian (VerfasserIn) , Plinkert, Peter K. (VerfasserIn) , Plath, Karim (VerfasserIn) , Heß, Jochen (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 18 May 2023
In: International journal of molecular sciences
Year: 2023, Jahrgang: 24, Heft: 10, Pages: 1-19
ISSN:1422-0067
DOI:10.3390/ijms24108938
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms24108938
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/24/10/8938
Volltext
Verfasserangaben:Christopher Weusthof, Sebastian Burkart, Karl Semmelmayer, Fabian Stögbauer, Bohai Feng, Karam Khorani, Sebastian Bode, Peter Plinkert, Karim Plath and Jochen Hess
Beschreibung
Zusammenfassung:Perineural invasion is a prevalent pathological finding in head and neck squamous cell carcinoma and a risk factor for unfavorable survival. An adequate diagnosis of perineural invasion by pathologic examination is limited due to the availability of tumor samples from surgical resection, which can arise in cases of definitive nonsurgical treatment. To address this medical need, we established a random forest prediction model for the risk assessment of perineural invasion, including occult perineural invasion, and characterized distinct cellular and molecular features based on our new and extended classification. RNA sequencing data of head and neck squamous cell carcinoma from The Cancer Genome Atlas were used as a training cohort to identify differentially expressed genes that are associated with perineural invasion. ...
Beschreibung:Gesehen am 21.11.2023
Beschreibung:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms24108938

Ähnliche Einträge