Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs
SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. Howe...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
05 July 2021
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| In: |
Cellular and molecular life sciences
Year: 2021, Jahrgang: 78, Heft: 16, Pages: 5953-5976 |
| ISSN: | 1420-9071 |
| DOI: | 10.1007/s00018-021-03889-5 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00018-021-03889-5
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| Verfasserangaben: | Sébastien Boutin, Dagmar Hildebrand, Steeve Boulant, Michael Kreuter, Jule Rüter, Srinivas Reddy Pallerla, Thirumalaisamy P. Velavan, Dennis Nurjadi |
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| 520 | |a SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host’s microbiome and secondary infection which also worsen the disease. | ||
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