Head-to-head intra-individual comparison of biodistribution and tumor uptake of (18F)FAPI-74 with (18F)FDG in patients with PDAC: a prospective exploratory study
Background: Radiolabeled fibroblast activation protein (FAP) ligands, a novel class of tracers for PET/CT imaging, have demonstrated very promising results in various oncological, as well as in some benign, diseases with long-term potential to supplant the current pan-cancer agent [18F]FDG in some c...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2023
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| In: |
Cancers
Year: 2023, Jahrgang: 15, Heft: 10, Pages: 1-13 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers15102798 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers15102798 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/15/10/2798 
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| Verfasserangaben: | Emil Novruzov, Frederik L. Giesel, Yuriko Mori, Peter L. Choyke, Mardjan Dabir, Eduards Mamlins, Dominik Schmitt, Christina Antke, Claudio Pinto, Cristian Soza-Ried, Rene Fernandez, Horacio Amaral, Vasko Kramer and Leonardo Badinez |
MARC
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| 245 | 1 | 0 | |a Head-to-head intra-individual comparison of biodistribution and tumor uptake of (18F)FAPI-74 with (18F)FDG in patients with PDAC |b a prospective exploratory study |c Emil Novruzov, Frederik L. Giesel, Yuriko Mori, Peter L. Choyke, Mardjan Dabir, Eduards Mamlins, Dominik Schmitt, Christina Antke, Claudio Pinto, Cristian Soza-Ried, Rene Fernandez, Horacio Amaral, Vasko Kramer and Leonardo Badinez |
| 246 | 3 | 3 | |a Head-to-head intra-individual comparison of biodistribution and tumor uptake of (18 F)FAPI-74 with (18 F)FDG in patients with PDAC |
| 264 | 1 | |c 2023 | |
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| 500 | |a Veröffentlicht: 17. Mai 2023 | ||
| 500 | |a Gesehen am 26.07.2023 | ||
| 500 | |a Im Titel ist der Ausdruck "18F" eckig geklammert und die Zahl 18 hochgestellt | ||
| 520 | |a Background: Radiolabeled fibroblast activation protein (FAP) ligands, a novel class of tracers for PET/CT imaging, have demonstrated very promising results in various oncological, as well as in some benign, diseases with long-term potential to supplant the current pan-cancer agent [18F]FDG in some cancer types. Pancreatic ductal carcinoma (PDAC) belongs to the group of epithelial malignancies with a strong so-called “desmoplastic reaction”, leading to a prominent tumor stroma with cancer-associated fibroblasts that exhibit a marked overexpression of fibroblast activation protein (FAP). The first clinical experiences in PDAC with 68Ga-labeled FAP ligands suggested superior sensitivity to [18F]FDG. However, there is limited data with 18F-labeled FAP derivatives, i.e. [18F]FAPI-74, yet prospective single- and multicenter trials are already ongoing. In this proof-of-concept study, we sought to evaluate the biodistribution, tumor uptake, and lesion detectability in patients with PDAC using [18F]FAPI-74 PET/CT as compared to [18F]FDG PET/CT scans for staging. Methods: This study includes 7 patients (median age 69) who underwent both [18F]FDG PET/CT with contrast-enhancement and [18F]FAPI-74 PET with low-dose CT for primary staging (n = 3) and therapy response control after neoadjuvant (n = 1) or re-staging after palliative therapy (n = 3). The mean interval between PET scans was 11 ± 4 days (range 1-15 days). The [18F]FDG and [18F]FAPI-74 PET/CT scans were acquired at 64 ± 4.1 min (range 61-91 min) and 66.4 ± 6.3 min (range 60-76 min), respectively, after administration of 200 ± 94 MBq (range 79-318 MBq) and 235 ± 88 MBq (range 90-321 MBq), respectively. Quantification of tracer uptake was determined with SUVmax and SUVmean. Furthermore, the tumor-to-background ratio (TBR) was derived by dividing the SUVmax of tumor lesions by the SUVmax of adipose tissue, skeletal muscle, and blood pool. Results: Overall, 32 lesions were detected in 7 patients including primary (n = 7), lung (n = 7), bone (n = 3), lymph node (n = 13), and peritoneal metastases (n = 2). [18F]FAPI-74 detected 22% more lesions compared with [18F]FDG with a better TBR and visual lesion delineation. In one patient the primary lesion could be detected unequivocally with [18F]FAPI-74 but was missed by [18F]FDG imaging. Altogether, most of the lesions demonstrated markedly elevated uptake of [18F]FAPI-74 with a simultaneous lower uptake in the background, providing a very high visual contrast. Conclusion: To the best of our knowledge, this is the first, prospective, intra-individual investigation comparing [18F]FAPI-74 with [18F]FDG imaging in PDAC with encouraging results. These pivotalresults supporta larger, multicentric, prospective study to determine the value of [18F]FAPI-74 in detecting and staging PDAC in comparison with current standard of care imaging. | ||
| 650 | 4 | |a FAPI | |
| 650 | 4 | |a FAPI-74 | |
| 650 | 4 | |a FDG | |
| 650 | 4 | |a fibroblast activation protein | |
| 650 | 4 | |a pancreas cancer | |
| 650 | 4 | |a PDAC | |
| 650 | 4 | |a PET | |
| 700 | 1 | |a Giesel, Frederik L. |d 1970- |e VerfasserIn |0 (DE-588)129031240 |0 (DE-627)387883878 |0 (DE-576)297457071 |4 aut | |
| 700 | 1 | |a Mori, Yuriko |e VerfasserIn |4 aut | |
| 700 | 1 | |a Choyke, Peter L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dabir, Mardjan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mamlins, Eduards |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmitt, Dominik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Antke, Christina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pinto, Claudio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Soza-Ried, Cristian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fernandez, Rene |e VerfasserIn |4 aut | |
| 700 | 1 | |a Amaral, Horacio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kramer, Vasko |e VerfasserIn |4 aut | |
| 700 | 1 | |a Badinez, Leonardo |e VerfasserIn |4 aut | |
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