Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance

In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG). Recent evidence strongly suggests that AQP4-Ab are directly involved in the immunopathogenesis of NMO.

Bibliographic Details

Main Authors:	Jarius, Sven (Author) , Franciotta, Diego (Author) , Paul, Friedemann (Author) , Ruprecht, Klemens (Author) , Bergamaschi, Roberto (Author) , Rommer, Paulus S. (Author) , Reuss, Reinhard (Author) , Probst, Christian (Author) , Kristoferitsch, Wolfgang (Author) , Wandinger, Klaus Peter (Author) , Wildemann, Brigitte (Author)
Format:	Article (Journal)
Language:	English
Published:	08 September 2010
In:	Journal of neuroinflammation Year: 2010, Volume: 7, Pages: 1-8
ISSN:	1742-2094
DOI:	10.1186/1742-2094-7-52
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1742-2094-7-52
Author Notes:	Sven Jarius, Diego Franciotta, Friedemann Paul, Klemens Ruprecht, Roberto Bergamaschi, Paulus S. Rommer, Reinhard Reuss, Christian Probst, Wolfgang Kristoferitsch, Klaus Peter Wandinger, Brigitte Wildemann