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Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance

In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG). Recent evidence strongly suggests that AQP4-Ab are directly involved in the immunopathogenesis of NMO.

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Bibliographic Details
Main Authors: Jarius, Sven (Author) , Franciotta, Diego (Author) , Paul, Friedemann (Author) , Ruprecht, Klemens (Author) , Bergamaschi, Roberto (Author) , Rommer, Paulus S. (Author) , Reuss, Reinhard (Author) , Probst, Christian (Author) , Kristoferitsch, Wolfgang (Author) , Wandinger, Klaus Peter (Author) , Wildemann, Brigitte (Author)
Format: Article (Journal)
Language:English
Published: 08 September 2010
In: Journal of neuroinflammation
Year: 2010, Volume: 7, Pages: 1-8
ISSN:1742-2094
DOI:10.1186/1742-2094-7-52
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1742-2094-7-52
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Author Notes:Sven Jarius, Diego Franciotta, Friedemann Paul, Klemens Ruprecht, Roberto Bergamaschi, Paulus S. Rommer, Reinhard Reuss, Christian Probst, Wolfgang Kristoferitsch, Klaus Peter Wandinger, Brigitte Wildemann

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