Differentiation of intracerebral tumor entities with quantitative contrast attenuation and iodine mapping in dual-layer Computed Tomography
Purpose: To investigate if quantitative contrast enhancement and iodine mapping of common brain tumor (BT) entities may correctly differentiate between tumor etiologies in standardized stereotactic CT protocols. Material and Methods: A retrospective monocentric study of 139 consecutive standardized...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 October 2022
|
| In: |
Diagnostics
Year: 2022, Volume: 12, Issue: 10 |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics12102494 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/diagnostics12102494 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2075-4418/12/10/2494 
|
| Author Notes: | Jan Borggrefe, Max Philipp Gebest, Myriam Hauger, Daniel Ruess, Anastasios Mpotsaris, Christoph Kabbasch, Lenhard Pennig, Kai Roman Laukamp, Lukas Goertz, Jan Robert Kroeger and Jonas Doerner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1854012304 | ||
| 003 | DE-627 | ||
| 005 | 20240307085607.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230801s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/diagnostics12102494 |2 doi | |
| 035 | |a (DE-627)1854012304 | ||
| 035 | |a (DE-599)KXP1854012304 | ||
| 035 | |a (OCoLC)1425217119 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Borggrefe, Jan |d 1982- |e VerfasserIn |0 (DE-588)142479594 |0 (DE-627)636298817 |0 (DE-576)330949977 |4 aut | |
| 245 | 1 | 0 | |a Differentiation of intracerebral tumor entities with quantitative contrast attenuation and iodine mapping in dual-layer Computed Tomography |c Jan Borggrefe, Max Philipp Gebest, Myriam Hauger, Daniel Ruess, Anastasios Mpotsaris, Christoph Kabbasch, Lenhard Pennig, Kai Roman Laukamp, Lukas Goertz, Jan Robert Kroeger and Jonas Doerner |
| 264 | 1 | |c 15 October 2022 | |
| 300 | |b Illustrationen | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a This article belongs to the special issue Advancements in Neuroimaging | ||
| 500 | |a Gesehen am 01.08.2023 | ||
| 520 | |a Purpose: To investigate if quantitative contrast enhancement and iodine mapping of common brain tumor (BT) entities may correctly differentiate between tumor etiologies in standardized stereotactic CT protocols. Material and Methods: A retrospective monocentric study of 139 consecutive standardized dual-layer dual-energy CT (dlDECT) scans conducted prior to the stereotactic needle biopsy of untreated primary brain tumor lesions. Attenuation of contrast-enhancing BT was derived from polyenergetic images as well as spectral iodine density maps (IDM) and their contrast-to-noise-ratios (CNR) were determined using ROI measures in contrast-enhancing BT and healthy contralateral white matter. The measures were correlated to histopathology regarding tumor entity, isocitrate dehydrogenase (IDH) and MGMT mutation status. Results: The cohort included 52 female and 76 male patients, mean age of 59.4 (±17.1) years. Brain lymphomas showed the highest attenuation (IDM CNR 3.28 ± 1,23), significantly higher than glioblastoma (2.37 ± 1.55, p < 0.005) and metastases (1.95 ± 1.14, p < 0.02), while the differences between glioblastomas and metastases were not significant. These strongly enhancing lesions differed from oligodendroglioma and astrocytoma (Grade II and III) that showed IDM CNR in the range of 1.22-1.27 (±0.45-0.82). Conventional attenuation measurements in DLCT data performed equally or slightly superior to iodine density measurements. Conclusion: Quantitative attenuation and iodine density measurements of contrast-enhancing brain tumors are feasible imaging biomarkers for the discrimination of cerebral tumor lesions but not specifically for single tumor entities. CNR based on simple HU measurements performed equally or slightly superior to iodine quantification. | ||
| 650 | 4 | |a dual-energy computed tomography | |
| 650 | 4 | |a iodine quantification | |
| 650 | 4 | |a neurooncology | |
| 650 | 4 | |a tumor differentiation | |
| 700 | 1 | |a Gebest, Max Philipp |d 1989- |e VerfasserIn |0 (DE-588)1222980169 |0 (DE-627)1742233430 |4 aut | |
| 700 | 1 | |a Hauger, Myriam |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ruess, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mpotsaris, Anastasios |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kabbasch, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pennig, Lenhard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Laukamp, Kai Roman |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goertz, Lukas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kroeger, Jan Robert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Doerner, Jonas |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Diagnostics |d Basel : MDPI, 2011 |g 12(2022), 10, Artikel-ID 2494 |h Online-Ressource |w (DE-627)718627814 |w (DE-600)2662336-5 |w (DE-576)365413917 |x 2075-4418 |7 nnas |a Differentiation of intracerebral tumor entities with quantitative contrast attenuation and iodine mapping in dual-layer Computed Tomography |
| 773 | 1 | 8 | |g volume:12 |g year:2022 |g number:10 |g elocationid:2494 |g extent:10 |a Differentiation of intracerebral tumor entities with quantitative contrast attenuation and iodine mapping in dual-layer Computed Tomography |
| 856 | 4 | 0 | |u https://doi.org/10.3390/diagnostics12102494 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2075-4418/12/10/2494 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230801 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1222980169 |a Gebest, Max Philipp |m 1222980169:Gebest, Max Philipp |d 60000 |d 63000 |e 60000PG1222980169 |e 63000PG1222980169 |k 0/60000/ |k 1/60000/63000/ |p 2 | ||
| 999 | |a KXP-PPN1854012304 |e 436171892X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Differentiation of intracerebral tumor entities with quantitative contrast attenuation and iodine mapping in dual-layer Computed Tomography","title":"Differentiation of intracerebral tumor entities with quantitative contrast attenuation and iodine mapping in dual-layer Computed Tomography"}],"person":[{"family":"Borggrefe","given":"Jan","display":"Borggrefe, Jan","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Gebest","given":"Max Philipp","roleDisplay":"VerfasserIn","display":"Gebest, Max Philipp","role":"aut"},{"given":"Myriam","family":"Hauger","role":"aut","roleDisplay":"VerfasserIn","display":"Hauger, Myriam"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Ruess, Daniel","given":"Daniel","family":"Ruess"},{"family":"Mpotsaris","given":"Anastasios","display":"Mpotsaris, Anastasios","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Kabbasch","given":"Christoph","display":"Kabbasch, Christoph","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Pennig, Lenhard","given":"Lenhard","family":"Pennig"},{"roleDisplay":"VerfasserIn","display":"Laukamp, Kai Roman","role":"aut","family":"Laukamp","given":"Kai Roman"},{"given":"Lukas","family":"Goertz","role":"aut","roleDisplay":"VerfasserIn","display":"Goertz, Lukas"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kroeger, Jan Robert","given":"Jan Robert","family":"Kroeger"},{"role":"aut","display":"Doerner, Jonas","roleDisplay":"VerfasserIn","given":"Jonas","family":"Doerner"}],"recId":"1854012304","language":["eng"],"note":["This article belongs to the special issue Advancements in Neuroimaging","Gesehen am 01.08.2023"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.3390/diagnostics12102494"],"eki":["1854012304"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"15 October 2022"}],"name":{"displayForm":["Jan Borggrefe, Max Philipp Gebest, Myriam Hauger, Daniel Ruess, Anastasios Mpotsaris, Christoph Kabbasch, Lenhard Pennig, Kai Roman Laukamp, Lukas Goertz, Jan Robert Kroeger and Jonas Doerner"]},"relHost":[{"id":{"zdb":["2662336-5"],"eki":["718627814"],"issn":["2075-4418"]},"origin":[{"dateIssuedDisp":"2011-","dateIssuedKey":"2011","publisher":"MDPI","publisherPlace":"Basel"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Diagnostics","subtitle":"open access journal","title_sort":"Diagnostics"}],"language":["eng"],"recId":"718627814","note":["Gesehen am 28.05.2020"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Differentiation of intracerebral tumor entities with quantitative contrast attenuation and iodine mapping in dual-layer Computed TomographyDiagnostics","part":{"volume":"12","text":"12(2022), 10, Artikel-ID 2494","extent":"10","year":"2022","issue":"10"},"pubHistory":["1.2011 -"]}],"physDesc":[{"noteIll":"Illustrationen","extent":"10 S."}]} | ||
| SRT | |a BORGGREFEJDIFFERENTI1520 | ||