Effects of vitamin D supplementation on inflammatory response in patients with cancer and precancerous lesions: systematic review and meta-analysis of randomized trials
Background & aims - Inflammation plays a key role in tumor development and progression. Vitamin D has potential tumor suppressing effects through modulation of inflammatory processes. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to summarize and...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2023
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| In: |
Clinical nutrition
Year: 2023, Jahrgang: 42, Heft: 7, Pages: 1142-1150 |
| ISSN: | 1532-1983 |
| DOI: | 10.1016/j.clnu.2023.05.009 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clnu.2023.05.009 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0261561423001516 
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| Verfasserangaben: | Tafirenyika Gwenzi, Anna Zhu, Petra Schrotz-King, Ben Schöttker, Michael Hoffmeister, Hermann Brenner |
MARC
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| 245 | 1 | 0 | |a Effects of vitamin D supplementation on inflammatory response in patients with cancer and precancerous lesions |b systematic review and meta-analysis of randomized trials |c Tafirenyika Gwenzi, Anna Zhu, Petra Schrotz-King, Ben Schöttker, Michael Hoffmeister, Hermann Brenner |
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| 520 | |a Background & aims - Inflammation plays a key role in tumor development and progression. Vitamin D has potential tumor suppressing effects through modulation of inflammatory processes. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to summarize and evaluate the effects of vitamin D3 supplementation (VID3S) on serum inflammatory biomarkers among patients with cancer or pre-cancerous lesions. - Methods - We searched PubMed, Web of Science and Cochrane databases until November 2022. The effects of VID3S were estimated from pooled standardized mean differences (SMDs) with their 95% confidence intervals (CIs) for inflammatory biomarker follow-up levels between intervention and control groups. - Results - Meta-analysis of eight RCTs (total of 592 patients with cancer or pre-cancerous conditions) showed that VID3S significantly lowered levels of serum tumor necrosis factor (TNF)-α (SMD [95%CI]: −1.65 [−3.07; −0.24]). VID3S also resulted in statistically non-significantly lower serum levels of interleukin (IL)-6 (SMD [95%CI]: −0.83, [−1.78; 0.13]) and C-reactive protein (CRP) (SMD [95%CI]: −0.09, [−0.35; 0.16]), whereas IL-10 levels were unaltered (SMD [95%CI]: −0.00, [−0.50; 0.49]). - Conclusion - Our study shows evidence of a significant reduction of TNF-α levels by VID3S for patients with cancer or precancerous lesions. Patients with cancer or precancerous lesions may benefit from personalized VID3S in suppressing tumour-promoting inflammatory response. - Prospero registration number - CRD42022295694. | ||
| 650 | 4 | |a Biomarker | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Precancer | |
| 650 | 4 | |a Vitamin D3 supplement | |
| 700 | 1 | |a Zhu, Anna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schrotz-King, Petra |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Brenner, Hermann |e VerfasserIn |0 (DE-588)1020516445 |0 (DE-627)691247005 |0 (DE-576)360642136 |4 aut | |
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