Lung toxicity of lomustine in the treatment of progressive gliomas
Pulmonary fibrosis is a rare, but dangerous side effect of CCNU (lomustine). CCNU is a frequently used chemotherapeutic agent in the setting of recurrent or progressive glioblastoma. At present, CCNU is also administered in patients with newly diagnosed gliomas in combination with temozolomide. Ther...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2022
|
| In: |
Neuro-oncology advances
Year: 2022, Jahrgang: 4, Heft: 1, Pages: 1-7 |
| ISSN: | 2632-2498 |
| DOI: | 10.1093/noajnl/vdac068 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1093/noajnl/vdac068 Verlag, kostenfrei, Volltext: https://academic.oup.com/noa/article/4/1/vdac068/6583451?login=true 
|
| Verfasserangaben: | Corinna Seliger, Christina Nürnberg, Wolfgang Wick, and Antje Wick |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1854066773 | ||
| 003 | DE-627 | ||
| 005 | 20240306113313.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230801s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/noajnl/vdac068 |2 doi | |
| 035 | |a (DE-627)1854066773 | ||
| 035 | |a (DE-599)KXP1854066773 | ||
| 035 | |a (OCoLC)1425062290 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Seliger, Corinna |e VerfasserIn |0 (DE-588)1207951587 |0 (DE-627)1694290972 |4 aut | |
| 245 | 1 | 0 | |a Lung toxicity of lomustine in the treatment of progressive gliomas |c Corinna Seliger, Christina Nürnberg, Wolfgang Wick, and Antje Wick |
| 264 | 1 | |c 2022 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.08.2023 | ||
| 520 | |a Pulmonary fibrosis is a rare, but dangerous side effect of CCNU (lomustine). CCNU is a frequently used chemotherapeutic agent in the setting of recurrent or progressive glioblastoma. At present, CCNU is also administered in patients with newly diagnosed gliomas in combination with temozolomide. There is only little evidence if, and how, lung function should be monitored on treatment with CCNU.We retrospectively collected data on patient characteristics, lung function analyses, and relevant toxicities among 166 brain tumor patients treated with CCNU at a German University Hospital and National Cancer Center.The patient collective mainly included patients with recurrent glioblastoma who received a mean number of 2.64 ± 1.57 cycles. There was overall no statistically significant change in parameters of pulmonary restriction among patients treated with CCNU. On an individual patient basis, a >10% decrease in the absolute vital capacity was primarily seen in patients with prior lung diseases and smokers. Other severe toxicities mainly included thrombocytopenia, leukopenia, nausea, and vomiting.Our findings support to limit lung function analyses on CCNU to patients with gliomas and pulmonary risk factors. However, all patients should be closely followed for clinical symptoms of pulmonary restriction. | ||
| 700 | 1 | |a Nürnberg, Christina |e VerfasserIn |0 (DE-588)1187776300 |0 (DE-627)1666682217 |4 aut | |
| 700 | 1 | |a Wick, Wolfgang |d 1970- |e VerfasserIn |0 (DE-588)120297736 |0 (DE-627)080586929 |0 (DE-576)186221320 |4 aut | |
| 700 | 1 | |a Wick, Antje |d 1972- |e VerfasserIn |0 (DE-588)122759869 |0 (DE-627)706032101 |0 (DE-576)293409609 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuro-oncology advances |d Oxford : Oxford University Press, 2019 |g 4(2022), 1, Artikel-ID vdac068, Seite 1-7 |w (DE-627)1691023000 |w (DE-600)3009682-0 |x 2632-2498 |7 nnas |a Lung toxicity of lomustine in the treatment of progressive gliomas |
| 773 | 1 | 8 | |g volume:4 |g year:2022 |g number:1 |g elocationid:vdac068 |g pages:1-7 |g extent:7 |a Lung toxicity of lomustine in the treatment of progressive gliomas |
| 856 | 4 | 0 | |u https://doi.org/10.1093/noajnl/vdac068 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/noa/article/4/1/vdac068/6583451?login=true |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230801 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 122759869 |a Wick, Antje |m 122759869:Wick, Antje |d 910000 |d 911100 |d 50000 |e 910000PW122759869 |e 911100PW122759869 |e 50000PW122759869 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 4 |y j | ||
| 998 | |g 120297736 |a Wick, Wolfgang |m 120297736:Wick, Wolfgang |d 910000 |d 911100 |e 910000PW120297736 |e 911100PW120297736 |k 0/910000/ |k 1/910000/911100/ |p 3 | ||
| 998 | |g 1187776300 |a Nürnberg, Christina |m 1187776300:Nürnberg, Christina |d 910000 |d 911100 |e 910000PN1187776300 |e 911100PN1187776300 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 998 | |g 1207951587 |a Seliger, Corinna |m 1207951587:Seliger, Corinna |d 910000 |d 911100 |d 50000 |e 910000PS1207951587 |e 911100PS1207951587 |e 50000PS1207951587 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1854066773 |e 4361948283 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Corinna Seliger, Christina Nürnberg, Wolfgang Wick, and Antje Wick"]},"id":{"eki":["1854066773"],"doi":["10.1093/noajnl/vdac068"]},"recId":"1854066773","physDesc":[{"extent":"7 S."}],"relHost":[{"part":{"year":"2022","volume":"4","pages":"1-7","extent":"7","text":"4(2022), 1, Artikel-ID vdac068, Seite 1-7","issue":"1"},"id":{"issn":["2632-2498"],"eki":["1691023000"],"zdb":["3009682-0"]},"titleAlt":[{"title":"NOA"}],"pubHistory":["Volume 1, issue 1 (May/December 2019)-"],"name":{"displayForm":["Society for NeuroOncology ; European Association of Neuro-Oncology"]},"disp":"Lung toxicity of lomustine in the treatment of progressive gliomasNeuro-oncology advances","recId":"1691023000","note":["Gesehen am 27.08.2024"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"title":[{"subtitle":"NOA","title":"Neuro-oncology advances","title_sort":"Neuro-oncology advances"}],"origin":[{"publisherPlace":"Oxford","dateIssuedDisp":"[2019]-","publisher":"Oxford University Press"}]}],"person":[{"family":"Seliger","given":"Corinna","role":"aut","display":"Seliger, Corinna"},{"role":"aut","given":"Christina","family":"Nürnberg","display":"Nürnberg, Christina"},{"display":"Wick, Wolfgang","role":"aut","given":"Wolfgang","family":"Wick"},{"role":"aut","given":"Antje","family":"Wick","display":"Wick, Antje"}],"origin":[{"dateIssuedDisp":"2022","dateIssuedKey":"2022"}],"title":[{"title":"Lung toxicity of lomustine in the treatment of progressive gliomas","title_sort":"Lung toxicity of lomustine in the treatment of progressive gliomas"}],"note":["Gesehen am 01.08.2023"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"]} | ||
| SRT | |a SELIGERCORLUNGTOXICI2022 | ||