Genetic analysis of the ATG16L1 c.898A>G (p.T300A) variant in acute and chronic pancreatitis
Objectives - Human and animal studies suggest an important role of autophagy in the pathogenesis of pancreatitis. ATG16L1 (autophagy-related 16 like 1) is part of a protein complex that is involved in the formation of autophagosomes. The c.898A > G (p.T300A) variant of ATG16L1 is assoc...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
Oct 1, 2022
|
| In: |
Pancreas
Year: 2022, Jahrgang: 51, Heft: 9, Pages: ? |
| ISSN: | 1536-4828 |
| DOI: | 10.1097/MPA.0000000000002177 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/MPA.0000000000002177 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/pancreasjournal/Abstract/2022/10000/Genetic_Analysis_of_the_ATG16L1_c_898A_G__p_T300A_.24.aspx 
|
| Verfasserangaben: | Claudia Neubauer, Maren Ewers, Hans-Ulrich Schulz, Frank Ulrich Weiß, Felix Lämmerhirt, Markus M. Lerch, Peter Bugert, Olfert Landt, Hana Algül, Jonas Rosendahl, Heiko Witt |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1854257471 | ||
| 003 | DE-627 | ||
| 005 | 20240329080201.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230803s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/MPA.0000000000002177 |2 doi | |
| 035 | |a (DE-627)1854257471 | ||
| 035 | |a (DE-599)KXP1854257471 | ||
| 035 | |a (OCoLC)1425217104 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Neubauer, Claudia |e VerfasserIn |0 (DE-588)1298498864 |0 (DE-627)1854482718 |4 aut | |
| 245 | 1 | 0 | |a Genetic analysis of the ATG16L1 c.898A>G (p.T300A) variant in acute and chronic pancreatitis |c Claudia Neubauer, Maren Ewers, Hans-Ulrich Schulz, Frank Ulrich Weiß, Felix Lämmerhirt, Markus M. Lerch, Peter Bugert, Olfert Landt, Hana Algül, Jonas Rosendahl, Heiko Witt |
| 264 | 1 | |c Oct 1, 2022 | |
| 300 | |a ? | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.08.2023 | ||
| 520 | |a Objectives - Human and animal studies suggest an important role of autophagy in the pathogenesis of pancreatitis. ATG16L1 (autophagy-related 16 like 1) is part of a protein complex that is involved in the formation of autophagosomes. The c.898A > G (p.T300A) variant of ATG16L1 is associated with Crohn disease. In this study, we analyzed ATG16L1 c.898A > G (p.T300A) for an association with pancreatitis. - Methods - We genotyped 777 patients and 551 control subjects of German origin by melting curve analysis using fluorescence resonance energy transfer probes. The patient group included 429 patients with nonalcoholic chronic pancreatitis (CP), 141 patients with alcoholic CP, and 207 patients with acute pancreatitis (AP). We classified AP by severity according to the Atlanta symposium 1992. - Results - Allele and genotype frequencies of ATG16L1 c.898A > G (p.T300A) did not differ significantly between patients and controls (G allele frequencies: nonalcoholic CP, 49.9%; alcoholic CP, 48.2%; AP, 49.5%; controls, 52.7%). We found no significant association with the severity of AP either. - Conclusions - Our data do not support a role of ATG16L1 c.898A > G (p.T300A) in the pathogenesis of AP or CP or an influence on the severity of AP. | ||
| 700 | 1 | |a Ewers, Maren |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schulz, Hans-Ulrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weiß, Frank Ulrich |d 1964- |e VerfasserIn |0 (DE-588)173053033 |0 (DE-627)697977390 |0 (DE-576)133905608 |4 aut | |
| 700 | 1 | |a Lämmerhirt, Felix |d 1989- |e VerfasserIn |0 (DE-588)1195780745 |0 (DE-627)1677826940 |4 aut | |
| 700 | 1 | |a Lerch, Markus M. |e VerfasserIn |0 (DE-588)1071337971 |0 (DE-627)825714842 |0 (DE-576)433028769 |4 aut | |
| 700 | 1 | |a Bugert, Peter |d 1964- |e VerfasserIn |0 (DE-588)1025332342 |0 (DE-627)722074018 |0 (DE-576)370212169 |4 aut | |
| 700 | 1 | |a Landt, Olfert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Algül, Hana |d 1972- |e VerfasserIn |0 (DE-588)124015476 |0 (DE-627)08558391X |0 (DE-576)293982236 |4 aut | |
| 700 | 1 | |a Rosendahl, Jonas |d 1977- |e VerfasserIn |0 (DE-588)1020755024 |0 (DE-627)69133434X |0 (DE-576)361950845 |4 aut | |
| 700 | 1 | |a Witt, Heiko |d 1974- |e VerfasserIn |0 (DE-588)137482558 |0 (DE-627)592738310 |0 (DE-576)303791926 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pancreas |d Philadelphia, Pa. : Lippincott Williams & Wilkins, 1986 |g 51(2022), 9, Artikel-ID 1231, Seite ? |h Online-Ressource |w (DE-627)332623130 |w (DE-600)2053902-2 |w (DE-576)09475294X |x 1536-4828 |7 nnas |a Genetic analysis of the ATG16L1 c.898A>G (p.T300A) variant in acute and chronic pancreatitis |
| 773 | 1 | 8 | |g volume:51 |g year:2022 |g number:9 |g elocationid:1231 |g pages:? |g extent:? |a Genetic analysis of the ATG16L1 c.898A>G (p.T300A) variant in acute and chronic pancreatitis |
| 856 | 4 | 0 | |u https://doi.org/10.1097/MPA.0000000000002177 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.lww.com/pancreasjournal/Abstract/2022/10000/Genetic_Analysis_of_the_ATG16L1_c_898A_G__p_T300A_.24.aspx |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230803 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1025332342 |a Bugert, Peter |m 1025332342:Bugert, Peter |d 60000 |d 63500 |e 60000PB1025332342 |e 63500PB1025332342 |k 0/60000/ |k 1/60000/63500/ |p 7 | ||
| 999 | |a KXP-PPN1854257471 |e 436269482X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"part":{"issue":"9","year":"2022","pages":"?","extent":"?","volume":"51","text":"51(2022), 9, Artikel-ID 1231, Seite ?"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Pancreas","title_sort":"Pancreas","subtitle":"official journal of the American Pancreatic Association and the Japan Pancreas Society"}],"disp":"Genetic analysis of the ATG16L1 c.898A>G (p.T300A) variant in acute and chronic pancreatitisPancreas","origin":[{"dateIssuedDisp":"1986-","dateIssuedKey":"1986","publisherPlace":"Philadelphia, Pa. ; [Erscheinungsort nicht ermittelbar]","publisher":"Lippincott Williams & Wilkins ; Ovid"}],"recId":"332623130","id":{"eki":["332623130"],"zdb":["2053902-2"],"issn":["1536-4828"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 07.06.2019"],"pubHistory":["1.1986 -"],"language":["eng"]}],"title":[{"title":"Genetic analysis of the ATG16L1 c.898A>G (p.T300A) variant in acute and chronic pancreatitis","title_sort":"Genetic analysis of the ATG16L1 c.898A>G (p.T300A) variant in acute and chronic pancreatitis"}],"physDesc":[{"extent":"? S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1854257471"],"doi":["10.1097/MPA.0000000000002177"]},"recId":"1854257471","origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"Oct 1, 2022"}],"name":{"displayForm":["Claudia Neubauer, Maren Ewers, Hans-Ulrich Schulz, Frank Ulrich Weiß, Felix Lämmerhirt, Markus M. Lerch, Peter Bugert, Olfert Landt, Hana Algül, Jonas Rosendahl, Heiko Witt"]},"language":["eng"],"note":["Gesehen am 03.08.2023"],"person":[{"display":"Neubauer, Claudia","role":"aut","family":"Neubauer","given":"Claudia"},{"display":"Ewers, Maren","role":"aut","family":"Ewers","given":"Maren"},{"family":"Schulz","role":"aut","display":"Schulz, Hans-Ulrich","given":"Hans-Ulrich"},{"given":"Frank Ulrich","display":"Weiß, Frank Ulrich","family":"Weiß","role":"aut"},{"given":"Felix","display":"Lämmerhirt, Felix","role":"aut","family":"Lämmerhirt"},{"given":"Markus M.","display":"Lerch, Markus M.","family":"Lerch","role":"aut"},{"given":"Peter","display":"Bugert, Peter","family":"Bugert","role":"aut"},{"given":"Olfert","role":"aut","family":"Landt","display":"Landt, Olfert"},{"given":"Hana","display":"Algül, Hana","family":"Algül","role":"aut"},{"display":"Rosendahl, Jonas","family":"Rosendahl","role":"aut","given":"Jonas"},{"display":"Witt, Heiko","family":"Witt","role":"aut","given":"Heiko"}]} | ||
| SRT | |a NEUBAUERCLGENETICANA1202 | ||