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Enantioselective iridium-catalyzed allylic substitutions with hydroxamic acid derivatives as N-nucleophiles

Enantioselective Ir-catalyzed allylic aminations with hydroxamic acid derivatives are described. Catalysts were prepared in situ from [Ir(cod)Cl]2 or [Ir(dbcot)Cl]2, a phosphoramidite and base. In addition, pure (π-allyl)Ir complexes containing cod or dbcot as auxiliary ligands were used. Very high...

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Hauptverfasser: Gärtner, Martin (VerfasserIn) , Jäkel, Mascha (VerfasserIn) , Achatz, Manuel (VerfasserIn) , Sonnenschein-Battefeld, Christoph (VerfasserIn) , Tverskoy, Olena (VerfasserIn) , Helmchen, Günter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2 May 2011
In: Organic letters
Year: 2011, Jahrgang: 13, Heft: 11, Pages: 2810-2813
ISSN:1523-7052
DOI:10.1021/ol200688d
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1021/ol200688d
Volltext
Verfasserangaben:Martin Gärtner, Mascha Jäkel, Manuel Achatz, Christoph Sonnenschein, Olena Tverskoy, and Günter Helmchen
Beschreibung
Zusammenfassung:Enantioselective Ir-catalyzed allylic aminations with hydroxamic acid derivatives are described. Catalysts were prepared in situ from [Ir(cod)Cl]2 or [Ir(dbcot)Cl]2, a phosphoramidite and base. In addition, pure (π-allyl)Ir complexes containing cod or dbcot as auxiliary ligands were used. Very high degrees of regio- and enantioselectivity were achieved. The reaction products were transformed into piperidine derivatives suited as precursors for aza-sugars.
Beschreibung:Gesehen am 03.08.2023
Beschreibung:Online Resource
ISSN:1523-7052
DOI:10.1021/ol200688d

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