In vitro models of the blood-cerebrospinal fluid barrier and their applications in the development and research of (neuro)pharmaceuticals
The pharmaceutical research sector has been facing the challenge of neurotherapeutics development and its inherited high-risk and high-failure-rate nature for decades. This hurdle is partly attributable to the presence of brain barriers, considered both as obstacles and opportunities for the entry o...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 August 2022
|
| In: |
Pharmaceutics
Year: 2022, Volume: 14, Issue: 8, Pages: 1-38 |
| ISSN: | 1999-4923 |
| DOI: | 10.3390/pharmaceutics14081729 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/pharmaceutics14081729 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1999-4923/14/8/1729 
|
| Author Notes: | Fatemeh Dabbagh, Horst Schroten and Christian Schwerk |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1854474677 | ||
| 003 | DE-627 | ||
| 005 | 20240306113218.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230807s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/pharmaceutics14081729 |2 doi | |
| 035 | |a (DE-627)1854474677 | ||
| 035 | |a (DE-599)KXP1854474677 | ||
| 035 | |a (OCoLC)1425062391 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Dabbagh, Fatemeh |e VerfasserIn |0 (DE-588)1298483506 |0 (DE-627)1854474278 |4 aut | |
| 245 | 1 | 0 | |a In vitro models of the blood-cerebrospinal fluid barrier and their applications in the development and research of (neuro)pharmaceuticals |c Fatemeh Dabbagh, Horst Schroten and Christian Schwerk |
| 246 | 3 | 3 | |a In vitro models of the blood-cerebrospinal fluid barrier and their applications in the development and research of neuropharmaceuticals |
| 264 | 1 | |c 18 August 2022 | |
| 300 | |b Illustrationen | ||
| 300 | |a 38 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.08.2023 | ||
| 520 | |a The pharmaceutical research sector has been facing the challenge of neurotherapeutics development and its inherited high-risk and high-failure-rate nature for decades. This hurdle is partly attributable to the presence of brain barriers, considered both as obstacles and opportunities for the entry of drug substances. The blood-cerebrospinal fluid (CSF) barrier (BCSFB), an under-studied brain barrier site compared to the blood-brain barrier (BBB), can be considered a potential therapeutic target to improve the delivery of CNS therapeutics and provide brain protection measures. Therefore, leveraging robust and authentic in vitro models of the BCSFB can diminish the time and effort spent on unproductive or redundant development activities by a preliminary assessment of the desired physiochemical behavior of an agent toward this barrier. To this end, the current review summarizes the efforts and progresses made to this research area with a notable focus on the attribution of these models and applied techniques to the pharmaceutical sector and the development of neuropharmacological therapeutics and diagnostics. A survey of available in vitro models, with their advantages and limitations and cell lines in hand will be provided, followed by highlighting the potential applications of such models in the (neuro)therapeutics discovery and development pipelines. | ||
| 650 | 4 | |a BCSFB | |
| 650 | 4 | |a blood-cerebrospinal fluid barrier | |
| 650 | 4 | |a choroid plexus | |
| 650 | 4 | |a drug permeability | |
| 650 | 4 | |a drugs | |
| 650 | 4 | |a in vitro model | |
| 650 | 4 | |a therapeutics | |
| 700 | 1 | |a Schroten, Horst |d 1957- |e VerfasserIn |0 (DE-588)1031228837 |0 (DE-627)736021612 |0 (DE-576)378668226 |4 aut | |
| 700 | 1 | |a Schwerk, Christian |d 1967- |e VerfasserIn |0 (DE-588)1043971785 |0 (DE-627)771149158 |0 (DE-576)176759735 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pharmaceutics |d Basel : MDPI, 2009 |g 14(2022), 8 vom: Aug., Artikel-ID 1729, Seite 1-38 |h Online-Ressource |w (DE-627)614096529 |w (DE-600)2527217-2 |w (DE-576)313958653 |x 1999-4923 |7 nnas |a In vitro models of the blood-cerebrospinal fluid barrier and their applications in the development and research of (neuro)pharmaceuticals |
| 773 | 1 | 8 | |g volume:14 |g year:2022 |g number:8 |g month:08 |g elocationid:1729 |g pages:1-38 |g extent:38 |a In vitro models of the blood-cerebrospinal fluid barrier and their applications in the development and research of (neuro)pharmaceuticals |
| 856 | 4 | 0 | |u https://doi.org/10.3390/pharmaceutics14081729 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1999-4923/14/8/1729 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230807 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1043971785 |a Schwerk, Christian |m 1043971785:Schwerk, Christian |d 60000 |d 62300 |e 60000PS1043971785 |e 62300PS1043971785 |k 0/60000/ |k 1/60000/62300/ |p 3 |y j | ||
| 998 | |g 1031228837 |a Schroten, Horst |m 1031228837:Schroten, Horst |d 60000 |d 62300 |e 60000PS1031228837 |e 62300PS1031228837 |k 0/60000/ |k 1/60000/62300/ |p 2 | ||
| 998 | |g 1298483506 |a Dabbagh, Fatemeh |m 1298483506:Dabbagh, Fatemeh |d 60000 |d 62300 |e 60000PD1298483506 |e 62300PD1298483506 |k 0/60000/ |k 1/60000/62300/ |p 1 |x j | ||
| 999 | |a KXP-PPN1854474677 |e 4363541237 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"18 August 2022"}],"note":["Gesehen am 07.08.2023"],"physDesc":[{"extent":"38 S.","noteIll":"Illustrationen"}],"relHost":[{"name":{"displayForm":["Molecular Diversity Preservation International"]},"pubHistory":["1.2009 -"],"recId":"614096529","id":{"issn":["1999-4923"],"eki":["614096529"],"zdb":["2527217-2"]},"title":[{"title_sort":"Pharmaceutics","title":"Pharmaceutics"}],"part":{"volume":"14","extent":"38","text":"14(2022), 8 vom: Aug., Artikel-ID 1729, Seite 1-38","year":"2022","pages":"1-38","issue":"8"},"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisherPlace":"Basel","dateIssuedDisp":"2009-","publisher":"MDPI","dateIssuedKey":"2009"}],"language":["eng"],"disp":"In vitro models of the blood-cerebrospinal fluid barrier and their applications in the development and research of (neuro)pharmaceuticalsPharmaceutics","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 28.05.14"]}],"language":["eng"],"id":{"eki":["1854474677"],"doi":["10.3390/pharmaceutics14081729"]},"recId":"1854474677","name":{"displayForm":["Fatemeh Dabbagh, Horst Schroten and Christian Schwerk"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Dabbagh, Fatemeh","given":"Fatemeh","family":"Dabbagh"},{"role":"aut","family":"Schroten","given":"Horst","roleDisplay":"VerfasserIn","display":"Schroten, Horst"},{"role":"aut","given":"Christian","roleDisplay":"VerfasserIn","display":"Schwerk, Christian","family":"Schwerk"}],"titleAlt":[{"title":"In vitro models of the blood-cerebrospinal fluid barrier and their applications in the development and research of neuropharmaceuticals"}],"title":[{"title_sort":"In vitro models of the blood-cerebrospinal fluid barrier and their applications in the development and research of (neuro)pharmaceuticals","title":"In vitro models of the blood-cerebrospinal fluid barrier and their applications in the development and research of (neuro)pharmaceuticals"}]} | ||
| SRT | |a DABBAGHFATINVITROMOD1820 | ||