Enantioselective total synthesis of (−)-α-kainic acid
An enantioselective total synthesis of (−)-α-kainic acid is described. Key steps are an Ir-catalyzed allylic amination with a propargylic amine to provide an enyne and a diastereoselective intramolecular Pauson−Khand reaction. Subsequent steps involve a Baeyer−Villiger reaction, reduction of the res...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 February 2010
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| In: |
Organic letters
Year: 2010, Jahrgang: 12, Heft: 5, Pages: 1108-1111 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/ol1001076 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/ol1001076
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| Verfasserangaben: | Andreas Farwick and Günter Helmchen |
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| 520 | |a An enantioselective total synthesis of (−)-α-kainic acid is described. Key steps are an Ir-catalyzed allylic amination with a propargylic amine to provide an enyne and a diastereoselective intramolecular Pauson−Khand reaction. Subsequent steps involve a Baeyer−Villiger reaction, reduction of the resulting lactone, and direct Jones oxidation of a silyl ether. | ||
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