Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibers
Classically, to electrically excite C-nociceptors, rectangular pulses are used with a duration close to the estimated chronaxie of C-fibres (about 2 ms). Recent results using slow depolarizing stimuli suggest longer chronaxies. We therefore set out to optimize C-fiber stimulation based on recordings...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 2023
|
| In: |
The journal of pain
Year: 2023, Volume: 24, Issue: 6, Pages: 957-969 |
| ISSN: | 1528-8447 |
| DOI: | 10.1016/j.jpain.2023.01.009 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jpain.2023.01.009 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1526590023000172 
|
| Author Notes: | Tobias Schneider, Julia Filip, Sabrina Soares, Kyra Sohns, Richard Carr, Roman Rukwied, Martin Schmelz |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1854657607 | ||
| 003 | DE-627 | ||
| 005 | 20240916072346.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230808s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jpain.2023.01.009 |2 doi | |
| 035 | |a (DE-627)1854657607 | ||
| 035 | |a (DE-599)KXP1854657607 | ||
| 035 | |a (OCoLC)1425213350 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schneider, Tobias |e VerfasserIn |0 (DE-588)1298786630 |0 (DE-627)1854658220 |4 aut | |
| 245 | 1 | 0 | |a Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibers |c Tobias Schneider, Julia Filip, Sabrina Soares, Kyra Sohns, Richard Carr, Roman Rukwied, Martin Schmelz |
| 264 | 1 | |c June 2023 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 18. Januar 2023, Artikelversion: 6. Juni 2023 | ||
| 500 | |a Gesehen am 08.08.2023 | ||
| 520 | |a Classically, to electrically excite C-nociceptors, rectangular pulses are used with a duration close to the estimated chronaxie of C-fibres (about 2 ms). Recent results using slow depolarizing stimuli suggest longer chronaxies. We therefore set out to optimize C-fiber stimulation based on recordings of single C-nociceptors in-vivo and C-fiber compound-action-potentials (C-CAP) ex-vivo using half-sine shaped stimuli of durations between 1 and 250ms. Single fiber (n = 45) recording in pigs revealed high chronaxie values for C-touch fibers (15.8 ms), polymodal- (14.2 ms) and silent-nociceptors (16.8 ms). Activation thresholds decreased 2 to 3-fold in all fibre classes when increasing the duration of half-sine pulses from 1 to 25 ms (P < .05). C-CAPs strength-duration curves of the pig saphenous nerve (n = 7) showed the highest sensitivity for half-sine durations between 10 and 25 ms. Half-maximum currents for C-CAPS were reduced 3-fold compared to rectangular pulses (P < .01) whereas the opposite was found for A-fiber compound action potentials. Psychophysics in humans (n = 23) revealed that half-sine stimulus durations >10 ms reduced detection thresholds, pain thresholds, and stimulus current amplitudes required to generate a pain rating of 3 on an 11-point Numeric Rating Scale (NRS) as compared to 1 ms rectangular pulses (P < 0.05). Increasing the duration from 1 to 25 ms led to a 4-fold amplitude reduction for pain-thresholds and stimuli caused an axon-reflex flare. Excitability of single polymodal nociceptors in animals paralleled human psychophysics and we conclude optimized half-sine pulses facilitate C-nociceptor activation. - Perspective - Electrical stimulation with longer lasting half-sine wave pulses preferentially activates C-nociceptors and changes in the strength duration curve may identify nociceptor hyperexcitability in patients with neuropathic pain. | ||
| 650 | 4 | |a C-nociceptor activation | |
| 650 | 4 | |a chronaxie | |
| 650 | 4 | |a current strength-duration | |
| 650 | 4 | |a half-sine wave | |
| 650 | 4 | |a rectangular pulse | |
| 700 | 1 | |a Filip, Julia |d 1995- |e VerfasserIn |0 (DE-588)1341651290 |0 (DE-627)1902326768 |4 aut | |
| 700 | 1 | |a Soares, Sabrina |d 1984- |e VerfasserIn |0 (DE-588)1228107106 |0 (DE-627)1749401614 |4 aut | |
| 700 | 1 | |a Sohns, Kyra |d 1995- |e VerfasserIn |0 (DE-588)1277811741 |0 (DE-627)1830839241 |4 aut | |
| 700 | 1 | |a Carr, Richard |d 1970- |e VerfasserIn |0 (DE-588)1034395483 |0 (DE-627)745445942 |0 (DE-576)382000579 |4 aut | |
| 700 | 1 | |a Rukwied, Roman |d 1963- |e VerfasserIn |0 (DE-588)121127486 |0 (DE-627)08110524X |0 (DE-576)29255026X |4 aut | |
| 700 | 1 | |a Schmelz, Martin |d 1962- |e VerfasserIn |0 (DE-588)115466517 |0 (DE-627)691338027 |0 (DE-576)289899427 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of pain |d New York, NY : Elsevier, 2000 |g 24(2023), 6 vom: Juni, Seite 957-969 |h Online-Ressource |w (DE-627)326172262 |w (DE-600)2040378-1 |w (DE-576)271585366 |x 1528-8447 |7 nnas |a Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibers |
| 773 | 1 | 8 | |g volume:24 |g year:2023 |g number:6 |g month:06 |g pages:957-969 |g extent:13 |a Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibers |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jpain.2023.01.009 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1526590023000172 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230808 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 115466517 |a Schmelz, Martin |m 115466517:Schmelz, Martin |d 60000 |d 65100 |e 60000PS115466517 |e 65100PS115466517 |k 0/60000/ |k 1/60000/65100/ |p 7 |y j | ||
| 998 | |g 121127486 |a Rukwied, Roman |m 121127486:Rukwied, Roman |d 60000 |d 65100 |d 60000 |e 60000PR121127486 |e 65100PR121127486 |e 60000PR121127486 |k 0/60000/ |k 1/60000/65100/ |k 0/60000/ |p 6 | ||
| 998 | |g 1034395483 |a Carr, Richard |m 1034395483:Carr, Richard |d 60000 |d 65100 |d 60000 |e 60000PC1034395483 |e 65100PC1034395483 |e 60000PC1034395483 |k 0/60000/ |k 1/60000/65100/ |k 0/60000/ |p 5 | ||
| 998 | |g 1277811741 |a Sohns, Kyra |m 1277811741:Sohns, Kyra |d 60000 |d 65100 |e 60000PS1277811741 |e 65100PS1277811741 |k 0/60000/ |k 1/60000/65100/ |p 4 | ||
| 998 | |g 1228107106 |a Soares, Sabrina |m 1228107106:Soares, Sabrina |d 60000 |e 60000PS1228107106 |k 0/60000/ |p 3 | ||
| 998 | |g 1341651290 |a Filip, Julia |m 1341651290:Filip, Julia |d 60000 |e 60000PF1341651290 |k 0/60000/ |p 2 | ||
| 998 | |g 1298786630 |a Schneider, Tobias |m 1298786630:Schneider, Tobias |p 1 |x j | ||
| 999 | |a KXP-PPN1854657607 |e 4363866810 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibers","title_sort":"Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibers"}],"person":[{"given":"Tobias","family":"Schneider","display":"Schneider, Tobias","role":"aut"},{"role":"aut","family":"Filip","given":"Julia","display":"Filip, Julia"},{"role":"aut","given":"Sabrina","family":"Soares","display":"Soares, Sabrina"},{"role":"aut","display":"Sohns, Kyra","family":"Sohns","given":"Kyra"},{"role":"aut","display":"Carr, Richard","family":"Carr","given":"Richard"},{"role":"aut","display":"Rukwied, Roman","family":"Rukwied","given":"Roman"},{"display":"Schmelz, Martin","given":"Martin","family":"Schmelz","role":"aut"}],"origin":[{"dateIssuedDisp":"June 2023","dateIssuedKey":"2023"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Online verfügbar: 18. Januar 2023, Artikelversion: 6. Juni 2023","Gesehen am 08.08.2023"],"id":{"eki":["1854657607"],"doi":["10.1016/j.jpain.2023.01.009"]},"recId":"1854657607","relHost":[{"note":["Gesehen am 15.01.20"],"pubHistory":["1.2000 -"],"title":[{"title":"The journal of pain","subtitle":"official journal of the American Pain Society","title_sort":"journal of pain"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedKey":"2000","publisher":"Elsevier ; Churchill Livingstone","dateIssuedDisp":"2000-","publisherPlace":"New York, NY ; Orlando, Fla."}],"part":{"pages":"957-969","volume":"24","extent":"13","issue":"6","year":"2023","text":"24(2023), 6 vom: Juni, Seite 957-969"},"corporate":[{"display":"American Pain Society","role":"isb"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibersThe journal of pain","language":["eng"],"id":{"issn":["1528-8447"],"zdb":["2040378-1"],"eki":["326172262"]},"recId":"326172262"}],"name":{"displayForm":["Tobias Schneider, Julia Filip, Sabrina Soares, Kyra Sohns, Richard Carr, Roman Rukwied, Martin Schmelz"]},"physDesc":[{"extent":"13 S."}],"language":["eng"]} | ||
| SRT | |a SCHNEIDERTOPTIMIZEDE2023 | ||