Vacuum-assisted breast biopsy after neoadjuvant systemic treatment for reliable exclusion of residual cancer in breast cancer patients
About 40 % of women with breast cancer achieve a pathologic complete response in the breast after neoadjuvant systemic treatment (NST). To identify these women, vacuum-assisted biopsy (VAB) was evaluated to facilitate risk-adaptive surgery. In confirmatory trials, the rates of missed residual cancer...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2022
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| In: |
Annals of surgical oncology
Year: 2022, Volume: 29, Issue: 2, Pages: 1076-1084 |
| ISSN: | 1534-4681 |
| DOI: | 10.1245/s10434-021-10847-9 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1245/s10434-021-10847-9 |
| Author Notes: | Vivian Koelbel, André Pfob, Benedikt Schaefgen, Peter Sinn, Manuel Feisst, Michael Golatta, Christina Gomez, Anne Stieber, Paul Bach, Geraldine Rauch, Joerg Heil |
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| 520 | |a About 40 % of women with breast cancer achieve a pathologic complete response in the breast after neoadjuvant systemic treatment (NST). To identify these women, vacuum-assisted biopsy (VAB) was evaluated to facilitate risk-adaptive surgery. In confirmatory trials, the rates of missed residual cancer [false-negative rates (FNRs)] were unacceptably high (> 10%). This analysis aimed to improve the ability of VAB to exclude residual cancer in the breast reliably by identifying key characteristics of false-negative cases. | ||
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